International Review of Neurobiology

, volume 151 , pages 299-324

Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

Irina Lyakhova ¹

Mariia A. Piatkova ¹

Valeriia Gulaia ²

Aleksandr Romanishin ²

Mikhail E. Shmelev ²

A. S. Bryukhovetskiy ³

Ankur Sharma ⁴

Hari Shanker Sharma ⁴

RODION KHOTIMCHENKO ^{1, 5}

I. S. Bryukhovetskiy ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia |

Laboratory of Biomedical Cell Technologies, Department of Medical Biology and Biotechnology, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia |

NeuroVita Clinic of Interventional and Restorative Neurology and Therapy, Moscow, Russia |

⁴

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, S-75185 Uppsala, Sweden |

⁵

Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia |

Publication type: Book Chapter

Publication date: 2020-05-13

Elsevier

International Review of Neurobiology

scimago Q4

SJR: 0.116

CiteScore: 4.0

Impact factor: —

ISSN: 00747742, 21625514

DOI: 10.1016/bs.irn.2020.03.010

Copy DOI

PubMed ID: 32448613

Abstract

Glioblastoma is one of the most aggressive human brain tumors. Even following all the modern protocols of complex treatment, the median patient survival typically does not exceed 15 months. This review analyzes the main reasons for glioblastoma resistance to therapy, as well as attempts at categorizing the main approaches to increasing chemotherapy efficiency. Special emphasis is placed on the specific group of compounds, known as marine alkaloids and their synthetic derivatives exerting a general antitumor effect on glioblastoma cells. The unique mechanisms of marine alkaloid influence on the tumor cells prompt considering them as a promising basis for creating new chemotherapeutic agents for glioblastoma treatment.

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GOST |

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GOST Copy

Lyakhova I. et al. Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review // International Review of Neurobiology. 2020. Vol. 151. pp. 299-324.

GOST all authors (up to 50) Copy

Lyakhova I., Piatkova M. A., Gulaia V., Romanishin A., Shmelev M. E., Bryukhovetskiy A. S., Sharma A., Sharma H. S., KHOTIMCHENKO R., Bryukhovetskiy I. S. Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review // International Review of Neurobiology. 2020. Vol. 151. pp. 299-324.

RIS |

Cite this

RIS Copy

TY - GENERIC

DO - 10.1016/bs.irn.2020.03.010

UR - https://doi.org/10.1016/bs.irn.2020.03.010

TI - Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

T2 - International Review of Neurobiology

AU - Lyakhova, Irina

AU - Piatkova, Mariia A.

AU - Gulaia, Valeriia

AU - Romanishin, Aleksandr

AU - Shmelev, Mikhail E.

AU - Bryukhovetskiy, A. S.

AU - Sharma, Ankur

AU - Sharma, Hari Shanker

AU - KHOTIMCHENKO, RODION

AU - Bryukhovetskiy, I. S.

PY - 2020

DA - 2020/05/13

PB - Elsevier

SP - 299-324

VL - 151

PMID - 32448613

SN - 0074-7742

SN - 2162-5514

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@incollection{2020_Lyakhova,

author = {Irina Lyakhova and Mariia A. Piatkova and Valeriia Gulaia and Aleksandr Romanishin and Mikhail E. Shmelev and A. S. Bryukhovetskiy and Ankur Sharma and Hari Shanker Sharma and RODION KHOTIMCHENKO and I. S. Bryukhovetskiy},

title = {Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review},

publisher = {Elsevier},

year = {2020},

volume = {151},

pages = {299--324},

month = {may}

}

Publisher

Elsevier

Journal

International Review of Neurobiology

scimago Q4

SJR

0.116

CiteScore

4.0

Impact factor

—

ISSN

00747742 (Print)

21625514

Profiles

Ankur M Sharma