Estrogen Receptors Modulation of Anxiety-Like Behavior
Publication type: Book Chapter
Publication date: 2017-01-01
PubMed ID:
28061972
Abstract
Estrogens exert profound effects on the expression of anxiety in humans and rodents; however, the directionality of these effects varies considerably within both clinical and preclinical literature. It is believed that discrepancies regarding the nature of estrogens’ effects on anxiety are attributable to the differential effects of specific estrogen receptor (ER) subtypes. In this chapter we will discuss the relative impact on anxiety and anxiety-like behavior of each of the three main ERs: ERα, which has a generally anxiogenic effect, ERβ, which has a generally anxiolytic effect, and the G-protein-coupled ER known as GPR30, which has been found to both increase and decrease anxiety-like behavior. In addition, we will describe the known mechanisms by which these receptor subtypes exert their influence on emotional responses, focusing on the hypothalamic–pituitary–adrenal axis and the oxytocinergic and serotonergic systems. The impact of estrogens on the expression of anxiety is likely the result of their combined effects on all of these neurobiological systems.
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121
Total citations:
121
Citations from 2024:
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(28.1%)
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GOST
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Borrow A. P., Handa R. J. Estrogen Receptors Modulation of Anxiety-Like Behavior // Vitamins and Hormones. 2017. Vol. 103. pp. 27-52.
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Borrow A. P., Handa R. J. Estrogen Receptors Modulation of Anxiety-Like Behavior // Vitamins and Hormones. 2017. Vol. 103. pp. 27-52.
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RIS
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TY - GENERIC
DO - 10.1016/bs.vh.2016.08.004
UR - https://doi.org/10.1016/bs.vh.2016.08.004
TI - Estrogen Receptors Modulation of Anxiety-Like Behavior
T2 - Vitamins and Hormones
AU - Borrow, Amanda P
AU - Handa, R. J.
PY - 2017
DA - 2017/01/01
PB - Elsevier
SP - 27-52
VL - 103
PMID - 28061972
SN - 0083-6729
ER -
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@incollection{2017_Borrow,
author = {Amanda P Borrow and R. J. Handa},
title = {Estrogen Receptors Modulation of Anxiety-Like Behavior},
publisher = {Elsevier},
year = {2017},
volume = {103},
pages = {27--52},
month = {jan}
}