In situ dsDNA-bevacizumab anticancer monoclonal antibody interaction electrochemical evaluation
2
Serviços Farmacêuticos, Centro Hospitalar e Universitário de Coimbra, EPE, 3000-075 Coimbra, Portugal
|
Publication type: Journal Article
Publication date: 2015-10-14
scimago Q1
wos Q1
SJR: 1.004
CiteScore: 10.4
Impact factor: 6.0
ISSN: 00032670, 18734324
PubMed ID:
26526907
Biochemistry
Spectroscopy
Analytical Chemistry
Environmental Chemistry
Abstract
The interaction of the anticancer monoclonal antibody bevacizumab (BEVA) with double-stranded DNA (dsDNA) was studied by voltammetry and gel-electrophoresis in incubated samples and using the dsDNA-electrochemical biosensor. The voltammetric results revealed a decrease and disappearance of the dsDNA oxidation peaks with increasing incubation time, showing that BEVA binds to the dsDNA but no DNA oxidative damage was detected electrochemically. Non denaturing agarose gel-electrophoresis experiments were in agreement with the voltammetric results showing the formation of compact BEVA-dsDNA adduct. The dsDNA-electrochemical biosensor in incubated solutions showed that BEVA also undergoes structural modification upon binding dsDNA, and BEVA electroactive amino acid residues oxidation peaks were detected.
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17
Total citations:
17
Citations from 2024:
1
(5.88%)
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GOST
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Tomé L. I. N. et al. In situ dsDNA-bevacizumab anticancer monoclonal antibody interaction electrochemical evaluation // Analytica Chimica Acta. 2015. Vol. 898. pp. 28-33.
GOST all authors (up to 50)
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Tomé L. I. N., Marques N., Diculescu V. C., Oliveira-Brett A. M. In situ dsDNA-bevacizumab anticancer monoclonal antibody interaction electrochemical evaluation // Analytica Chimica Acta. 2015. Vol. 898. pp. 28-33.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.aca.2015.09.049
UR - https://doi.org/10.1016/j.aca.2015.09.049
TI - In situ dsDNA-bevacizumab anticancer monoclonal antibody interaction electrochemical evaluation
T2 - Analytica Chimica Acta
AU - Tomé, Luciana I N
AU - Marques, Nuno
AU - Diculescu, Victor C
AU - Oliveira-Brett, Ana Maria
PY - 2015
DA - 2015/10/14
PB - Elsevier
SP - 28-33
VL - 898
PMID - 26526907
SN - 0003-2670
SN - 1873-4324
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Tomé,
author = {Luciana I N Tomé and Nuno Marques and Victor C Diculescu and Ana Maria Oliveira-Brett},
title = {In situ dsDNA-bevacizumab anticancer monoclonal antibody interaction electrochemical evaluation},
journal = {Analytica Chimica Acta},
year = {2015},
volume = {898},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.aca.2015.09.049},
pages = {28--33},
doi = {10.1016/j.aca.2015.09.049}
}