Open Access
IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases
1
Department of Dermatology
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Graduate School of Medical Sciences
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Fukuoka Japan
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Division of Medical Biochemistry Department of Biomolecular Sciences Saga Medical School Saga Japan
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6
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga Japan.
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Publication type: Journal Article
Publication date: 2020-07-01
scimago Q1
wos Q1
SJR: 1.627
CiteScore: 10.4
Impact factor: 6.7
ISSN: 13238930, 14401592
PubMed ID:
31980374
General Medicine
Immunology and Allergy
Abstract
Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4 + T cells, NK cells, mast cells, keratinocytes, bronchial epithelial cells, and myofibroblasts. Previous studies suggest that IL-24 plays an essential role in the pathogenesis of pro-inflammatory autoimmune disorders such as psoriasis, arthritis, and inflammatory bowel diseases. However, the role of IL-24 in the pathogenesis of allergic diseases has been elusive. It has already been reported that IL-24 is involved in the pathogenesis of allergic lung and skin diseases. Moreover, we have recently revealed for the first time the pivotal functions of IL-24 in IL-13–mediated skin barrier dysfunction in atopic dermatitis (AD), which is known to be a characteristic of AD caused by Th2 cytokines such as IL-4 or IL-13. In this review, we show recent advances in the basic characteristics of IL-24 and its novel functions in the pathogenesis of allergic skin inflammation, focusing on AD. A better understanding of the role of IL-24 in allergic diseases can lead to the development of new therapeutic options.
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Metrics
61
Total citations:
61
Citations from 2024:
26
(42.62%)
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MLA
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GOST
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Mitamura Y. et al. IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases // Allergology International. 2020. Vol. 69. No. 3. pp. 405-411.
GOST all authors (up to 50)
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Mitamura Y., Nunomura S., Furue M., Izuhara K. IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases // Allergology International. 2020. Vol. 69. No. 3. pp. 405-411.
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RIS
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TY - JOUR
DO - 10.1016/j.alit.2019.12.003
UR - https://doi.org/10.1016/j.alit.2019.12.003
TI - IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases
T2 - Allergology International
AU - Mitamura, Yasutaka
AU - Nunomura, Satoshi
AU - Furue, Masutaka
AU - Izuhara, Kenji
PY - 2020
DA - 2020/07/01
PB - Elsevier
SP - 405-411
IS - 3
VL - 69
PMID - 31980374
SN - 1323-8930
SN - 1440-1592
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Mitamura,
author = {Yasutaka Mitamura and Satoshi Nunomura and Masutaka Furue and Kenji Izuhara},
title = {IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases},
journal = {Allergology International},
year = {2020},
volume = {69},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.alit.2019.12.003},
number = {3},
pages = {405--411},
doi = {10.1016/j.alit.2019.12.003}
}
Cite this
MLA
Copy
Mitamura, Yasutaka, et al. “IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases.” Allergology International, vol. 69, no. 3, Jul. 2020, pp. 405-411. https://doi.org/10.1016/j.alit.2019.12.003.