American Journal of the Medical Sciences, volume 369, issue 2, pages 137-144
Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients
Dong Wang
1
,
Jing Jing Zhang
2
,
Yufei Zhao
2
,
Ruijie Cao
2
,
Yingnan Wang
3
,
Iren Guo
4
,
Chenxing Peng
5
,
Yanrong Song
6
,
Shasha Zhang
2
4
Emma Willard School, 285 Pawling Avenue, Troy, NY 12180
6
Department of Medical Technology, Xingtai Medical College, No. 618, Iron North Road, Xindu District, Xingtai City, Hebei Province
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Publication type: Journal Article
Publication date: 2025-02-01
scimago Q2
wos Q2
SJR: 0.681
CiteScore: 4.4
Impact factor: 2.3
ISSN: 00029629, 15382990
Abstract
MicroRNA (miRNA)-processing machinery may modify the risk of primary Sjögren's syndrome (pSS) by altering miRNA expression profiles. Inflammatory cytokines and reactive oxygen species (ROS) are also involved in pSS; however, the role of altered miRNAs expression in its pathogenesis is still unclear. We aimed to evaluate the relationship between single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), and the risk of pSS in female patients. The potential associations of cytokines and ROS with pSS-susceptible SNPs were also evaluated.
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