Microchamber wound dressings enable hierarchical functionality control over physiological processes via sustained chemical microenvironment modulation

Wound care remains a significant healthcare challenge, with associated costs continuing to rise over the past decade. The advancement of innovative wound dressings that actively facilitate healing has emerged as a pivotal research focus. This study introduces a novel design for functional microstructured wound dressings, utilising microencapsulation technology to enhance wound healing. This methodology allows for precise tuning of the chemical microenvironment within the wound bed. An original solid-powder encapsulation methodology is employed, facilitating the sustained and controlled release of bioactive compounds. The effects of sustained release are demonstrated by modulating oxidative stress through the administration of antioxidants and hydrogen peroxide. Sustained release of active compounds within the wound is shown to modulate angiogenesis, exert antiseptic and anti-inflammatory effects, and promote scar-free tissue formation. The fundamental role of ultralow doses and sustained-release of hydrogen peroxide and antioxidants in tissue regeneration was simultaneously investigated. The observed bioeffects of microchamber-based wound dressings highlight the potential of advanced materials and encapsulation strategies to actively regulate the wound milieu and provide sustained, tailored therapeutic effects by a slight shift of the chemical profile. The proposed technique establishes a foundation for the development of wound healing systems characterised by hierarchical multifunctionality. Our approach presents a variety of unique features and potential applications, including anisotropic manipulations, site specific and on-demand release, integration with cell therapy, and more. Further research is warranted to explore the clinical translation and broader applications of this technology for wound management.