Elsevier
Biochimica et Biophysica Acta - Molecular Basis of Disease
,  volume 1871 ,  issue 6 ,  pages 167843

Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis

Tomoyasu Yoshihiro 1
, 
KYOKO YAMAGUCHI 2
, 
Hiroshi Ariyama 1
, 
Sakuya Koreishi 1
, 
Koki Uehara 1
, 
Hirofumi Ohmura 3
, 
Mamoru Ito 2
, 
Kenji Tsuchihashi 2
, 
Taichi Isobe 3
, 
Koji Shindo 4
, 
Kenoki Ohuchida 4
, 
Masafumi Nakamura 4
, 
Yoshihiro Nagao 5
, 
Yoshinao Oda 6
, 
Koichi Akashi 1
, 
Eishi Baba 3
1
 
2
 
3
 
4
 
5
 
6
 
Publication type: Journal Article
Publication date: 2025-08-01
Elsevier
scimago Q1
wos Q1
SJR: 1.432
CiteScore: 6.8
Impact factor: 4.2
ISSN: 09254439, 1879260X
Abstract
BackgroundHelicobacter pylori infection and subsequent atrophic gastritis (AG) and intestinal metaplasia (IM) are regarded as precursor conditions for gastric cancer (GC). Though diverse mechanisms of carcinogenesis from AG and IM have been clarified using mouse models, few studies using human models have been reported. Here, we describe in vitro modeling of IM, as well as in vivo modeling of the oncogenic transformation from AG using human gastric organoids.
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Yoshihiro T. et al. Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2025. Vol. 1871. No. 6. p. 167843.
GOST all authors (up to 50) Copy
Yoshihiro T., YAMAGUCHI K., Ariyama H., Koreishi S., Uehara K., Ohmura H., Ito M., Tsuchihashi K., Isobe T., Shindo K., Ohuchida K., Nakamura M., Nagao Y., Oda Y., Akashi K., Baba E. Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2025. Vol. 1871. No. 6. p. 167843.
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TY - JOUR
DO - 10.1016/j.bbadis.2025.167843
UR - https://linkinghub.elsevier.com/retrieve/pii/S0925443925001887
TI - Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis
T2 - Biochimica et Biophysica Acta - Molecular Basis of Disease
AU - Yoshihiro, Tomoyasu
AU - YAMAGUCHI, KYOKO
AU - Ariyama, Hiroshi
AU - Koreishi, Sakuya
AU - Uehara, Koki
AU - Ohmura, Hirofumi
AU - Ito, Mamoru
AU - Tsuchihashi, Kenji
AU - Isobe, Taichi
AU - Shindo, Koji
AU - Ohuchida, Kenoki
AU - Nakamura, Masafumi
AU - Nagao, Yoshihiro
AU - Oda, Yoshinao
AU - Akashi, Koichi
AU - Baba, Eishi
PY - 2025
DA - 2025/08/01
PB - Elsevier
SP - 167843
IS - 6
VL - 1871
SN - 0925-4439
SN - 1879-260X
ER -
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@article{2025_Yoshihiro,
author = {Tomoyasu Yoshihiro and KYOKO YAMAGUCHI and Hiroshi Ariyama and Sakuya Koreishi and Koki Uehara and Hirofumi Ohmura and Mamoru Ito and Kenji Tsuchihashi and Taichi Isobe and Koji Shindo and Kenoki Ohuchida and Masafumi Nakamura and Yoshihiro Nagao and Yoshinao Oda and Koichi Akashi and Eishi Baba},
title = {Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis},
journal = {Biochimica et Biophysica Acta - Molecular Basis of Disease},
year = {2025},
volume = {1871},
publisher = {Elsevier},
month = {aug},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0925443925001887},
number = {6},
pages = {167843},
doi = {10.1016/j.bbadis.2025.167843}
}
MLA
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Yoshihiro, Tomoyasu, et al. “Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis.” Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1871, no. 6, Aug. 2025, p. 167843. https://linkinghub.elsevier.com/retrieve/pii/S0925443925001887.