,
volume 1865
,
issue 1
,
pages 158449
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Publication type: Journal Article
Publication date: 2020-01-01
scimago Q2
wos Q2
SJR: 1.212
CiteScore: 8.6
Impact factor: 3.3
ISSN: 13881981, 18792618
PubMed ID:
31028913
Molecular Biology
Cell Biology
Abstract
The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restore cellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programme regulates the expression of hundreds of genes in response to signalling from ATF6, IRE1, and PERK. These three highly conserved stress sensors are activated by the accumulation of unfolded proteins within the ER. Alternatively, IRE1 and PERK sense generalised lipid bilayer stress (LBS) at the ER while ATF6 is activated by an increase of specific sphingolipids. As a result, the UPR supports cellular robustness as a broad-spectrum compensatory pathway that is achieved by deploying a tailored transcriptional programme adapted to the source of ER stress. This review summarises the current understanding of the three ER stress transducers in sensing proteotoxic stress and LBS. The plasticity of the UPR programme in the context of different sources of ER stress will also be discussed.
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Citations from 2024:
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GOST
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Fun X. H., Thibault G. Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes // Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020. Vol. 1865. No. 1. p. 158449.
GOST all authors (up to 50)
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Fun X. H., Thibault G. Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes // Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020. Vol. 1865. No. 1. p. 158449.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bbalip.2019.04.009
UR - https://doi.org/10.1016/j.bbalip.2019.04.009
TI - Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
T2 - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
AU - Fun, Xiu Hui
AU - Thibault, Guillaume
PY - 2020
DA - 2020/01/01
PB - Elsevier
SP - 158449
IS - 1
VL - 1865
PMID - 31028913
SN - 1388-1981
SN - 1879-2618
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Fun,
author = {Xiu Hui Fun and Guillaume Thibault},
title = {Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes},
journal = {Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids},
year = {2020},
volume = {1865},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.bbalip.2019.04.009},
number = {1},
pages = {158449},
doi = {10.1016/j.bbalip.2019.04.009}
}
Cite this
MLA
Copy
Fun, Xiu Hui, and Guillaume Thibault. “Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes.” Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1865, no. 1, Jan. 2020, p. 158449. https://doi.org/10.1016/j.bbalip.2019.04.009.