Resistin: An inflammatory cytokine with multi-faceted roles in cancer
Sarabjeet Kour Sudan
1, 2
,
Sachin Kumar Deshmukh
1, 2
,
Teja Poosarla
3
,
Nicolette Paolaungthong Holliday
4
,
Donna Lynn Dyess
5
,
Seema Singh
1
Тип публикации: Journal Article
Дата публикации: 2020-12-01
scimago Q1
wos Q1
БС1
SJR: 2.885
CiteScore: 17.3
Impact factor: 8.3
ISSN: 0304419X, 18792561
PubMed ID:
32822824
Cancer Research
Oncology
Genetics
Краткое описание
Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pro-inflammatory properties, and its elevated serum levels are detected in cancer patients. Aberrant expression of resistin receptors is also reported in several malignancies and associated with aggressive clinicopathological features. Several lines of evidence demonstrate that resistin, acting through its different receptors, promotes tumor growth, metastasis, and chemoresistance by influencing a variety of cellular phenotypes as well as by modulating the tumor microenvironment. Racially disparate expression of resistin has also attracted much interest, considering prevalent cancer health disparities. This review discusses the aberrant expression of resistin and its receptors, its diverse downstream signaling and impact on tumor growth, metastasis, angiogenesis, and therapy resistance to support its clinical exploitation in biomarker and therapeutic development.
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MLA
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ГОСТ
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Sudan S. K. et al. Resistin: An inflammatory cytokine with multi-faceted roles in cancer // Biochimica et Biophysica Acta - Reviews on Cancer. 2020. Vol. 1874. No. 2. p. 188419.
ГОСТ со всеми авторами (до 50)
Скопировать
Sudan S. K., Deshmukh S. K., Poosarla T., Holliday N. P., Dyess D. L., Singh S. Resistin: An inflammatory cytokine with multi-faceted roles in cancer // Biochimica et Biophysica Acta - Reviews on Cancer. 2020. Vol. 1874. No. 2. p. 188419.
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RIS
Скопировать
TY - JOUR
DO - 10.1016/j.bbcan.2020.188419
UR - https://doi.org/10.1016/j.bbcan.2020.188419
TI - Resistin: An inflammatory cytokine with multi-faceted roles in cancer
T2 - Biochimica et Biophysica Acta - Reviews on Cancer
AU - Sudan, Sarabjeet Kour
AU - Deshmukh, Sachin Kumar
AU - Poosarla, Teja
AU - Holliday, Nicolette Paolaungthong
AU - Dyess, Donna Lynn
AU - Singh, Seema
PY - 2020
DA - 2020/12/01
PB - Elsevier
SP - 188419
IS - 2
VL - 1874
PMID - 32822824
SN - 0304-419X
SN - 1879-2561
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2020_Sudan,
author = {Sarabjeet Kour Sudan and Sachin Kumar Deshmukh and Teja Poosarla and Nicolette Paolaungthong Holliday and Donna Lynn Dyess and Seema Singh},
title = {Resistin: An inflammatory cytokine with multi-faceted roles in cancer},
journal = {Biochimica et Biophysica Acta - Reviews on Cancer},
year = {2020},
volume = {1874},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.bbcan.2020.188419},
number = {2},
pages = {188419},
doi = {10.1016/j.bbcan.2020.188419}
}
Цитировать
MLA
Скопировать
Sudan, Sarabjeet Kour, et al. “Resistin: An inflammatory cytokine with multi-faceted roles in cancer.” Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1874, no. 2, Dec. 2020, p. 188419. https://doi.org/10.1016/j.bbcan.2020.188419.