Biochemical and Biophysical Research Communications, volume 468, issue 4, pages 733-738
High-affinity interaction between interleukin-11 and S100P protein.
Kazakov Alexei S
1
,
Sokolov Andrei
1
,
Solovyev Valery
2
,
Ismailov Ramis G
1
,
Mikhailov Roman V
3
,
Ulitin Andrei B
2
,
Yakovenko Andrey R
4
,
Mirzabekov Tajib A
5, 6
,
Permyakov Eugene A.
1
,
2
Biocad, Lubuchany, Moscow Region, 142380, Russia.
|
3
Antherix, Institutskaya Str. 7, Pushchino, Moscow Region, 142290, Russia.
|
4
CJSC R-Pharm, Berzarina Str. 19/1, Moscow, 123154, Russia.
|
5
Antherix, Institutskaya Str. 7, Pushchino, Moscow Region, 142290, Russia
|
6
Biomirex Inc., 304 Pleasant Str., Watertown, MA, 02472, USA.
|
Publication type: Journal Article
Publication date: 2015-12-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 0006291X, 10902104
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
Interleukin-11 (IL-11) and S100P are oncoproteins co-expressed in numerous cancers, which might favor their interaction during oncogenesis. We have explored the possibility of this interaction by surface plasmon resonance spectroscopy, intrinsic fluorescence, and chemical crosslinking. Recombinant forms of IL-11 and S100P interact with each other under physiological level of calcium ions. IL-11 molecule has at least two S100P-binding sites with dissociation constants of 32 nM and 288 nM, which is 5-13-fold lower than its affinity to extracellular domain of IL-11 receptor subunit α. S100P does not alter IL-11-induced STAT3 activation in HEK293 cells co-expressing IL-11 receptors, but could affect other tumorigenic signaling pathways. The highly specific IL-11 - S100P interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kazakov A. S. et al. High-affinity interaction between interleukin-11 and S100P protein. // Biochemical and Biophysical Research Communications. 2015. Vol. 468. No. 4. pp. 733-738.
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Kazakov A. S., Sokolov A., Rastrygina V. A., Solovyev V., Ismailov R. G., Mikhailov R. V., Ulitin A. B., Yakovenko A. R., Mirzabekov T. A., Permyakov E. A., Permyakov S. High-affinity interaction between interleukin-11 and S100P protein. // Biochemical and Biophysical Research Communications. 2015. Vol. 468. No. 4. pp. 733-738.
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TY - JOUR
DO - 10.1016/j.bbrc.2015.11.024
UR - https://doi.org/10.1016%2Fj.bbrc.2015.11.024
TI - High-affinity interaction between interleukin-11 and S100P protein.
T2 - Biochemical and Biophysical Research Communications
AU - Kazakov, Alexei S
AU - Ismailov, Ramis G
AU - Mikhailov, Roman V
AU - Ulitin, Andrei B
AU - Yakovenko, Andrey R
AU - Mirzabekov, Tajib A
AU - Permyakov, Sergei
AU - Sokolov, Andrei
AU - Rastrygina, Victoria A
AU - Solovyev, Valery
AU - Permyakov, Eugene A.
PY - 2015
DA - 2015/12/01 00:00:00
PB - Elsevier
SP - 733-738
IS - 4
VL - 468
SN - 0006-291X
SN - 1090-2104
ER -
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@article{2015_Kazakov,
author = {Alexei S Kazakov and Ramis G Ismailov and Roman V Mikhailov and Andrei B Ulitin and Andrey R Yakovenko and Tajib A Mirzabekov and Sergei Permyakov and Andrei Sokolov and Victoria A Rastrygina and Valery Solovyev and Eugene A. Permyakov},
title = {High-affinity interaction between interleukin-11 and S100P protein.},
journal = {Biochemical and Biophysical Research Communications},
year = {2015},
volume = {468},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.bbrc.2015.11.024},
number = {4},
pages = {733--738},
doi = {10.1016/j.bbrc.2015.11.024}
}
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Kazakov, Alexei S., et al. “High-affinity interaction between interleukin-11 and S100P protein..” Biochemical and Biophysical Research Communications, vol. 468, no. 4, Dec. 2015, pp. 733-738. https://doi.org/10.1016%2Fj.bbrc.2015.11.024.
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