High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors
Publication type: Journal Article
Publication date: 2017-11-01
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
PubMed ID:
28870804
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
Abnormal expression and dysfunction of adiponectin and the cognate receptors are involved in diabetes and diabetic kidney disease (DKD), whereas angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) alleviate diabetic albuminuria and prevent development of DKD through upregulation of adiponectin expression. Here we report that high glucose stimulates expression of angiotensin II (AngII) receptors (AT1 and AT2) in renal proximal tubular epithelial cells (NRK-52E). These receptors underwent hetero-dimerization with adiponectin receptor AdipoR1 and AdipoR2, respectively. High glucose inhibited the dimerization between AT1 and AT2. Interestingly, these hetero-dimers instigated tubulointerstitial injury by inhibiting the cytoprotective action of the adiponectin receptors. These modes of receptor-receptor hetero-dimerization may contribute to high glucose-induced renal tubulointerstitial injury and could be potential therapeutic targets.
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GOST
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Zha D. et al. High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors // Biochemical and Biophysical Research Communications. 2017. Vol. 493. No. 1. pp. 840-846.
GOST all authors (up to 50)
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Zha D., Cheng H., Li W., Wu Y., Li X., Zhang L., Feng Y., Wu X. High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors // Biochemical and Biophysical Research Communications. 2017. Vol. 493. No. 1. pp. 840-846.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bbrc.2017.08.047
UR - https://doi.org/10.1016/j.bbrc.2017.08.047
TI - High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors
T2 - Biochemical and Biophysical Research Communications
AU - Zha, Dongqing
AU - Cheng, Huaiyan
AU - Li, Wei-wei
AU - Wu, Yizhe
AU - Li, Xiaoning
AU - Zhang, Lian
AU - Feng, Ying-Hong
AU - Wu, Xiaoyan
PY - 2017
DA - 2017/11/01
PB - Elsevier
SP - 840-846
IS - 1
VL - 493
PMID - 28870804
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Zha,
author = {Dongqing Zha and Huaiyan Cheng and Wei-wei Li and Yizhe Wu and Xiaoning Li and Lian Zhang and Ying-Hong Feng and Xiaoyan Wu},
title = {High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors},
journal = {Biochemical and Biophysical Research Communications},
year = {2017},
volume = {493},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bbrc.2017.08.047},
number = {1},
pages = {840--846},
doi = {10.1016/j.bbrc.2017.08.047}
}
Cite this
MLA
Copy
Zha, Dongqing, et al. “High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors.” Biochemical and Biophysical Research Communications, vol. 493, no. 1, Nov. 2017, pp. 840-846. https://doi.org/10.1016/j.bbrc.2017.08.047.