Biochemical and Biophysical Research Communications, volume 566, pages 45-52
Analysis of the molecular mechanism of SARS-CoV-2 antibodies
Publication type: Journal Article
Publication date: 2021-08-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 0006291X, 10902104
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
A newly-emergent beta-coronavirus, SARS-CoV-2, rapidly has become a pandemic since 2020. It is a serious respiratory disease and caused more than 100 million of deaths in the world. WHO named it COVIA-19 and there is no effective targeted drug for it. The main treatment strategies include chemical medicine, traditional Chinese medicine (TCM) and biologics. Due to SARS-CoV-2 uses the spike proteins (S proteins) on its envelope to infect human cells, monoclonal antibodies that neutralize the S protein have become one of the hot research areas in the current research and treatment of SARS-CoV-2. In this study, we reviewed the antibodies that have been reported to have neutralizing activity against the SARS-CoV-2 infection. According to their different binding epitope regions in RBD or NTD, they are classified, and the mechanism of the representative antibodies in each category is discussed in depth, which provides potential foundation for future antibody and vaccine therapy and the development of antibody cocktails against SARS-CoV-2 mutants.
Top-30
Citations by journals
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Frontiers in Immunology
2 publications, 11.76%
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PLoS ONE
1 publication, 5.88%
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Applied Sciences (Switzerland)
1 publication, 5.88%
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Frontiers in Microbiology
1 publication, 5.88%
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Vaccines
1 publication, 5.88%
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Nature Communications
1 publication, 5.88%
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Reviews in Medical Virology
1 publication, 5.88%
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Life Sciences
1 publication, 5.88%
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Respiratory Research
1 publication, 5.88%
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Plant Biotechnology Journal
1 publication, 5.88%
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Protein Engineering, Design and Selection
1 publication, 5.88%
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Russian Chemical Reviews
1 publication, 5.88%
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Structure
1 publication, 5.88%
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Citations by publishers
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3
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Frontiers Media S.A.
3 publications, 17.65%
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 11.76%
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Springer Nature
2 publications, 11.76%
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Wiley
2 publications, 11.76%
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Elsevier
2 publications, 11.76%
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Cold Spring Harbor Laboratory
2 publications, 11.76%
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Public Library of Science (PLoS)
1 publication, 5.88%
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Oxford University Press
1 publication, 5.88%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 5.88%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Jin D., Wei J., Sun J. Analysis of the molecular mechanism of SARS-CoV-2 antibodies // Biochemical and Biophysical Research Communications. 2021. Vol. 566. pp. 45-52.
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Jin D., Wei J., Sun J. Analysis of the molecular mechanism of SARS-CoV-2 antibodies // Biochemical and Biophysical Research Communications. 2021. Vol. 566. pp. 45-52.
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TY - JOUR
DO - 10.1016/j.bbrc.2021.06.001
UR - https://doi.org/10.1016/j.bbrc.2021.06.001
TI - Analysis of the molecular mechanism of SARS-CoV-2 antibodies
T2 - Biochemical and Biophysical Research Communications
AU - Jin, Dongfu
AU - Wei, Jing
AU - Sun, Jian
PY - 2021
DA - 2021/08/01 00:00:00
PB - Elsevier
SP - 45-52
VL - 566
SN - 0006-291X
SN - 1090-2104
ER -
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@article{2021_Jin,
author = {Dongfu Jin and Jing Wei and Jian Sun},
title = {Analysis of the molecular mechanism of SARS-CoV-2 antibodies},
journal = {Biochemical and Biophysical Research Communications},
year = {2021},
volume = {566},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bbrc.2021.06.001},
pages = {45--52},
doi = {10.1016/j.bbrc.2021.06.001}
}