Role of PPARα in inflammatory response of C2C12 myotubes
Yuki Shimizu
1
,
Keiko Hamada
1
,
Tingting Guo
1
,
Chie Hasegawa
1
,
Yusuke Kuga
1
,
Kazuki Takeda
1
,
Takashi Yagi
1
,
Hiroyuki Koyama
1
,
Hiroshi Takagi
2
,
Daisuke Aotani
1
,
Hiromi Kataoka
1
,
Tomohiro Tanaka
3
Publication type: Journal Article
Publication date: 2024-01-01
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
PubMed ID:
38141556
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
Recent studies have shown a role of inflammation in muscle atrophy and sarcopenia. However, no anti-inflammatory pharmacotherapy has been established for the treatment of sarcopenia. Here, we investigate the potential role of PPARα and its ligands on inflammatory response and PGC-1α gene expression in LPS-treated C2C12 myotubes. Knockdown of PPARα, whose expression was upregulated upon differentiation, augmented IL-6 or TNFα gene expression. Conversely, PPARα overexpression or its activation by ligands suppressed 2-h LPS-induced cytokine expression, with pemafibrate attenuating NF-κB or STAT3 phosphorylation. Of note, reduction of PGC-1α gene expression by LPS treatment for 24 hours was partially reversed by fenofibrate. Our data demonstrate a critical inhibitory role of PPARα in inflammatory response of C2C12 myotubes and suggest a future possibility of PPARα ligands as a candidate for anti-inflammatory therapy against sarcopenia.
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Metrics
5
Total citations:
5
Citations from 2024:
5
(100%)
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GOST
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Shimizu Y. et al. Role of PPARα in inflammatory response of C2C12 myotubes // Biochemical and Biophysical Research Communications. 2024. Vol. 694. p. 149413.
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Shimizu Y., Hamada K., Guo T., Hasegawa C., Kuga Y., Takeda K., Yagi T., Koyama H., Takagi H., Aotani D., Kataoka H., Tanaka T. Role of PPARα in inflammatory response of C2C12 myotubes // Biochemical and Biophysical Research Communications. 2024. Vol. 694. p. 149413.
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RIS
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TY - JOUR
DO - 10.1016/j.bbrc.2023.149413
UR - https://doi.org/10.1016/j.bbrc.2023.149413
TI - Role of PPARα in inflammatory response of C2C12 myotubes
T2 - Biochemical and Biophysical Research Communications
AU - Shimizu, Yuki
AU - Hamada, Keiko
AU - Guo, Tingting
AU - Hasegawa, Chie
AU - Kuga, Yusuke
AU - Takeda, Kazuki
AU - Yagi, Takashi
AU - Koyama, Hiroyuki
AU - Takagi, Hiroshi
AU - Aotani, Daisuke
AU - Kataoka, Hiromi
AU - Tanaka, Tomohiro
PY - 2024
DA - 2024/01/01
PB - Elsevier
SP - 149413
VL - 694
PMID - 38141556
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Shimizu,
author = {Yuki Shimizu and Keiko Hamada and Tingting Guo and Chie Hasegawa and Yusuke Kuga and Kazuki Takeda and Takashi Yagi and Hiroyuki Koyama and Hiroshi Takagi and Daisuke Aotani and Hiromi Kataoka and Tomohiro Tanaka},
title = {Role of PPARα in inflammatory response of C2C12 myotubes},
journal = {Biochemical and Biophysical Research Communications},
year = {2024},
volume = {694},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.bbrc.2023.149413},
pages = {149413},
doi = {10.1016/j.bbrc.2023.149413}
}
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