mRNA encoding antibodies against hemagglutinin and nucleoprotein prevents influenza virus infection in vitro

Yana A. Zabrodskaya 1, 2, 3
, 
Nina Gavrilova 2, 3, 4
, 
E A Elpaeva 2, 5
, 
A. A. Lozhkov 2, 3
, 
Alexey Lozhkov 4
, 
V. V. Vysochinskaya 4
, 
O A Dobrovolskaya 2, 5
, 
O.V. Dovbysh 3, 6
, 
E L Zimmerman 2, 3, 4
, 
P.N. Dav 3, 6
, 
A.V. Brodskaia 2, 3, 4
, 
E I Sakhenberg 2, 5
, 
A A Shaldzhyan 5
, 
A.A. Demaev 3, 6
, 
M A Maslov 7
, 
Michael Maslov 8
, 
A. V. Vasin 2, 3
, 
Andrey Vasin 4
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
Publication type: Journal Article
Publication date: 2024-12-01
Elsevier
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
Abstract
The emergence of new influenza virus strains presents a continuous challenge for global public health. mRNA technology offers a promising platform for rapidly developing therapeutics, particularly monoclonal antibodies, that can protect against viral infections. In this study, we engineered mRNA constructs encoding two types of antibodies: secreted antibodies specific to the hemagglutinin of the influenza A virus, based on previously characterized Fi6 antibodies, and intracellular Fab fragments targeting the nucleoprotein of the influenza B virus, derived from the 2/3 antibodies. The administration of mRNA constructs in vitro resulted in the successful synthesis of functional antibodies, which exhibited antiviral activity against influenza viruses. This study confirms the feasibility of using mRNA technology to develop therapeutic antibodies against influenza virus infections. The findings pave the way for future clinical applications of mRNA-based therapeutics, enhancing preparedness for emerging viral threats.
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Zabrodskaya Y. A. et al. mRNA encoding antibodies against hemagglutinin and nucleoprotein prevents influenza virus infection in vitro // Biochemical and Biophysical Research Communications. 2024. Vol. 738. p. 150945.
GOST all authors (up to 50) Copy
Zabrodskaya Y. A., Gavrilova N., Elpaeva E. A., Lozhkov A. A., Lozhkov A., Vysochinskaya V. V., Dobrovolskaya O. A., Dovbysh O., Zimmerman E. L., Dav P., Brodskaia A., Sakhenberg E. I., Shaldzhyan A. A., Demaev A., Maslov M. A., Maslov M., Vasin A. V., Vasin A. mRNA encoding antibodies against hemagglutinin and nucleoprotein prevents influenza virus infection in vitro // Biochemical and Biophysical Research Communications. 2024. Vol. 738. p. 150945.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.bbrc.2024.150945
UR - https://linkinghub.elsevier.com/retrieve/pii/S0006291X24014815
TI - mRNA encoding antibodies against hemagglutinin and nucleoprotein prevents influenza virus infection in vitro
T2 - Biochemical and Biophysical Research Communications
AU - Zabrodskaya, Yana A.
AU - Gavrilova, Nina
AU - Elpaeva, E A
AU - Lozhkov, A. A.
AU - Lozhkov, Alexey
AU - Vysochinskaya, V. V.
AU - Dobrovolskaya, O A
AU - Dovbysh, O.V.
AU - Zimmerman, E L
AU - Dav, P.N.
AU - Brodskaia, A.V.
AU - Sakhenberg, E I
AU - Shaldzhyan, A A
AU - Demaev, A.A.
AU - Maslov, M A
AU - Maslov, Michael
AU - Vasin, A. V.
AU - Vasin, Andrey
PY - 2024
DA - 2024/12/01
PB - Elsevier
SP - 150945
VL - 738
PMID - 39504717
SN - 0006-291X
SN - 1090-2104
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Zabrodskaya,
author = {Yana A. Zabrodskaya and Nina Gavrilova and E A Elpaeva and A. A. Lozhkov and Alexey Lozhkov and V. V. Vysochinskaya and O A Dobrovolskaya and O.V. Dovbysh and E L Zimmerman and P.N. Dav and A.V. Brodskaia and E I Sakhenberg and A A Shaldzhyan and A.A. Demaev and M A Maslov and Michael Maslov and A. V. Vasin and Andrey Vasin},
title = {mRNA encoding antibodies against hemagglutinin and nucleoprotein prevents influenza virus infection in vitro},
journal = {Biochemical and Biophysical Research Communications},
year = {2024},
volume = {738},
publisher = {Elsevier},
month = {dec},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0006291X24014815},
pages = {150945},
doi = {10.1016/j.bbrc.2024.150945}
}