Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders
Lili Song
1
,
Huimin Liu
2
,
Hui Li
1
,
Weiyu Yang
1, 2
,
Hongqing Yin
1, 2
,
Jiayi Wang
1, 2
,
Maojuan Guo
3
,
Zhen Yang
4
Publication type: Journal Article
Publication date: 2024-12-01
scimago Q1
wos Q1
SJR: 1.599
CiteScore: 9.4
Impact factor: 5.6
ISSN: 00062952, 18732968
PubMed ID:
39424201
Abstract
N6-methyladenosine (m6A) is a prevalent mRNA modification in eukaryotic cells, characterized by its reversible nature. YTH structural domain family protein 2 (YTHDF2), a key reader of m6A, plays a crucial role in identifying and binding m6A-containing RNAs, thereby influencing RNA metabolism through various functional mechanisms. The upstream and downstream targets of YTHDF2 are critical in the pathogenesis of various central nervous system (CNS) diseases, affecting disease development by regulating signaling pathways and gene expression. This paper provides an overview of current research on the role of YTHDF2 in CNS diseases and investigates the regulatory mechanisms by which YTHDF2 influences the development of these conditions. This exploration aims to improve understanding of disease pathogenesis and offer novel insights for the targeted prevention and treatment of neurological disorders.
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Total citations:
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Citations from 2024:
4
(100%)
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GOST
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Song L. et al. Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders // Biochemical Pharmacology. 2024. Vol. 230. No. Pt 1. p. 116576.
GOST all authors (up to 50)
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Song L., Liu H., Li H., Yang W., Yin H., Wang J., Guo M., Yang Z. Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders // Biochemical Pharmacology. 2024. Vol. 230. No. Pt 1. p. 116576.
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RIS
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TY - JOUR
DO - 10.1016/j.bcp.2024.116576
UR - https://linkinghub.elsevier.com/retrieve/pii/S0006295224005768
TI - Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders
T2 - Biochemical Pharmacology
AU - Song, Lili
AU - Liu, Huimin
AU - Li, Hui
AU - Yang, Weiyu
AU - Yin, Hongqing
AU - Wang, Jiayi
AU - Guo, Maojuan
AU - Yang, Zhen
PY - 2024
DA - 2024/12/01
PB - Elsevier
SP - 116576
IS - Pt 1
VL - 230
PMID - 39424201
SN - 0006-2952
SN - 1873-2968
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Song,
author = {Lili Song and Huimin Liu and Hui Li and Weiyu Yang and Hongqing Yin and Jiayi Wang and Maojuan Guo and Zhen Yang},
title = {Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders},
journal = {Biochemical Pharmacology},
year = {2024},
volume = {230},
publisher = {Elsevier},
month = {dec},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0006295224005768},
number = {Pt 1},
pages = {116576},
doi = {10.1016/j.bcp.2024.116576}
}
Cite this
MLA
Copy
Song, Lili, et al. “Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders.” Biochemical Pharmacology, vol. 230, no. Pt 1, Dec. 2024, p. 116576. https://linkinghub.elsevier.com/retrieve/pii/S0006295224005768.