Open Access
Urea removal strategies for dialysate regeneration in a wearable artificial kidney
Maaike K Gelder
1
,
Yong Guo
2
,
Christian Blüchel
3
,
Mathieu Odijk
4
,
Cornelus F. van Nostrum
2
,
Wim E. Hennink
2
,
Karin G.M. Gerritsen
1
3
Dialyss Pte Ltd, 21 Tampines Avenue 1, 529757, Singapore.
|
Publication type: Journal Article
Publication date: 2020-03-01
scimago Q1
wos Q1
SJR: 2.998
CiteScore: 28.5
Impact factor: 12.9
ISSN: 01429612, 18785905
PubMed ID:
31958714
Ceramics and Composites
Biophysics
Bioengineering
Biomaterials
Mechanics of Materials
Abstract
The availability of a wearable artificial kidney (WAK) that provides dialysis outside the hospital would be an important advancement for dialysis patients. The concept of a WAK is based on regeneration of a small volume of dialysate in a closed-loop. Removal of urea, the primary waste product of nitrogen metabolism, is the major challenge for the realization of a WAK since it is a molecule with low reactivity that is difficult to adsorb while it is the waste solute with the highest daily molar production. Currently, no efficient urea removal technology is available that allows for miniaturization of the WAK to a size and weight that is acceptable for patients to carry. Several urea removal strategies have been explored, including enzymatic hydrolysis by urease, electro-oxidation and sorbent systems. However, thus far, these methods have toxic side effects, limited removal capacity or slow removal kinetics. This review discusses different urea removal strategies for application in a wearable dialysis device, from both a chemical and a medical perspective.
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104
Total citations:
104
Citations from 2024:
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(48.07%)
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Gelder M. K. et al. Urea removal strategies for dialysate regeneration in a wearable artificial kidney // Biomaterials. 2020. Vol. 234. p. 119735.
GOST all authors (up to 50)
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Gelder M. K., Guo Y., Blüchel C., Verhaar M. C., Odijk M., van Nostrum C. F., Hennink W. E., Gerritsen K. G. Urea removal strategies for dialysate regeneration in a wearable artificial kidney // Biomaterials. 2020. Vol. 234. p. 119735.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.biomaterials.2019.119735
UR - https://doi.org/10.1016/j.biomaterials.2019.119735
TI - Urea removal strategies for dialysate regeneration in a wearable artificial kidney
T2 - Biomaterials
AU - Gelder, Maaike K
AU - Guo, Yong
AU - Blüchel, Christian
AU - Verhaar, Marianne C
AU - Odijk, Mathieu
AU - van Nostrum, Cornelus F.
AU - Hennink, Wim E.
AU - Gerritsen, Karin G.M.
PY - 2020
DA - 2020/03/01
PB - Elsevier
SP - 119735
VL - 234
PMID - 31958714
SN - 0142-9612
SN - 1878-5905
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Gelder,
author = {Maaike K Gelder and Yong Guo and Christian Blüchel and Marianne C Verhaar and Mathieu Odijk and Cornelus F. van Nostrum and Wim E. Hennink and Karin G.M. Gerritsen},
title = {Urea removal strategies for dialysate regeneration in a wearable artificial kidney},
journal = {Biomaterials},
year = {2020},
volume = {234},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.biomaterials.2019.119735},
pages = {119735},
doi = {10.1016/j.biomaterials.2019.119735}
}