Open Access
Roles of pyroptosis in atherosclerosis pathogenesis
Xiaohan Liu
1
,
Peiyi Luo
1
,
Weiyun Zhang
1
,
Shuxian Zhang
1
,
Shu-Long Yang
2, 3, 4
,
Fashui Hong
1
4
Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344000, China
|
Publication type: Journal Article
Publication date: 2023-10-01
scimago Q1
wos Q1
SJR: 1.775
CiteScore: 12.8
Impact factor: 7.5
ISSN: 07533322, 19506007
PubMed ID:
37643484
General Medicine
Pharmacology
Abstract
Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by gasdermin protein-mediated membrane pore formation, cell swelling, and rapid lysis. Recent studies have suggested that pyroptosis is closely related to atherosclerosis (AS). Previous studies reported that pyroptosis involving endothelial cells (ECs), macrophages, and smooth muscle cells (SMCs) plays an important role in the formation and development of AS. Pyroptosis not only causes local inflammation but also amplifies the inflammatory response and it aggravates plaque instability, leading to plaque rupture and thrombosis, eventually resulting in acute cardiovascular events. In this review, we clarified some novel pathways and mechanics and presented some potential drugs.
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Metrics
21
Total citations:
21
Citations from 2024:
20
(95.23%)
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GOST |
RIS |
BibTex
Cite this
GOST
Copy
Liu X. et al. Roles of pyroptosis in atherosclerosis pathogenesis // Biomedicine and Pharmacotherapy. 2023. Vol. 166. p. 115369.
GOST all authors (up to 50)
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Liu X., Luo P., Zhang W., Zhang S., Yang S., Hong F. Roles of pyroptosis in atherosclerosis pathogenesis // Biomedicine and Pharmacotherapy. 2023. Vol. 166. p. 115369.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.biopha.2023.115369
UR - https://doi.org/10.1016/j.biopha.2023.115369
TI - Roles of pyroptosis in atherosclerosis pathogenesis
T2 - Biomedicine and Pharmacotherapy
AU - Liu, Xiaohan
AU - Luo, Peiyi
AU - Zhang, Weiyun
AU - Zhang, Shuxian
AU - Yang, Shu-Long
AU - Hong, Fashui
PY - 2023
DA - 2023/10/01
PB - Elsevier
SP - 115369
VL - 166
PMID - 37643484
SN - 0753-3322
SN - 1950-6007
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Liu,
author = {Xiaohan Liu and Peiyi Luo and Weiyun Zhang and Shuxian Zhang and Shu-Long Yang and Fashui Hong},
title = {Roles of pyroptosis in atherosclerosis pathogenesis},
journal = {Biomedicine and Pharmacotherapy},
year = {2023},
volume = {166},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.biopha.2023.115369},
pages = {115369},
doi = {10.1016/j.biopha.2023.115369}
}