Open Access
Open access
Elsevier
Biomedicine and Pharmacotherapy
,  volume 168 ,  pages 115722

Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism

Publication type: Journal Article
Publication date: 2023-12-01
Elsevier
scimago Q1
wos Q1
SJR: 1.775
CiteScore: 12.8
Impact factor: 7.5
ISSN: 07533322, 19506007
General Medicine
Pharmacology
Abstract
Albeit remarkable achievements in anti-cancer endeavors, the prevention and treatment of cancer remain unresolved challenges. Hence, there is an urgent need to explore new and efficacious natural compounds with potential anti-cancer therapeutic agents. One such group of compounds is alisols, tetracyclic triterpene alcohols extracted from alisma orientale. Alisols play a significant role in cancer therapy as they can suppress cancer cell proliferation and migration by regulating signaling pathways such as mTOR, Bax/Bcl-2, CHOP, caspase, NF-kB and IRE1. Pharmacokinetic studies showed that alisols can be absorbed entirely, rapidly, and evenly distributed in vivo. Moreover, alisols are low in toxicity and relatively safe to take. Remarkably, each alisol can be converted into many compounds with different pathways to their anti-cancer effects in the body. Thus, alisols are regarded as promising anti-cancer agents with minimal side effects and low drug resistance. This review will examine and discuss alisols' anti-cancer molecular mechanism, pharmacokinetics and metabolism. Based on a comprehensive analysis of nearly 20 years of research, we evaluate the therapeutic potential of alisols for various types of cancer and offer insights and strategies for developing new cancer treatments.
Found 
Found 

Top-30

Journals

1
Nutrients
Nutrients, 1, 50%
Nutrients
1 publication, 50%
Frontiers in Pharmacology
Frontiers in Pharmacology, 1, 50%
Frontiers in Pharmacology
1 publication, 50%
1

Publishers

1
MDPI
MDPI, 1, 50%
MDPI
1 publication, 50%
Frontiers Media S.A.
Frontiers Media S.A., 1, 50%
Frontiers Media S.A.
1 publication, 50%
1
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
2
Share
Cite this
GOST |
Cite this
GOST Copy
Wu Y. et al. Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism // Biomedicine and Pharmacotherapy. 2023. Vol. 168. p. 115722.
GOST all authors (up to 50) Copy
Wu Y., Wang X., Yang L., Kang S., Ge Y., Han Y., Fang H., Sun H. F. Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism // Biomedicine and Pharmacotherapy. 2023. Vol. 168. p. 115722.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.biopha.2023.115722
UR - https://doi.org/10.1016/j.biopha.2023.115722
TI - Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism
T2 - Biomedicine and Pharmacotherapy
AU - Wu, Yinqi
AU - Wang, Xijun
AU - Yang, Le
AU - Kang, Shuyu
AU - Ge, Yan
AU - Han, Ying
AU - Fang, Hua
AU - Sun, H. F.
PY - 2023
DA - 2023/12/01
PB - Elsevier
SP - 115722
VL - 168
PMID - 37865991
SN - 0753-3322
SN - 1950-6007
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Wu,
author = {Yinqi Wu and Xijun Wang and Le Yang and Shuyu Kang and Yan Ge and Ying Han and Hua Fang and H. F. Sun},
title = {Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism},
journal = {Biomedicine and Pharmacotherapy},
year = {2023},
volume = {168},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.biopha.2023.115722},
pages = {115722},
doi = {10.1016/j.biopha.2023.115722}
}