Open Access
L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury
Wenzhu Wang
1
,
Jingyu Zhao
2
,
Zihan Li
3
,
Xiaoyu Kang
4
,
Elena A Smirnova
5
,
Lixu Liu
6
,
Yan Yu
7
3
China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing, PR China; Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, PR China.
|
4
China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing, PR China.
|
Publication type: Journal Article
Publication date: 2024-06-01
scimago Q1
wos Q1
SJR: 1.775
CiteScore: 12.8
Impact factor: 7.5
ISSN: 07533322, 19506007
PubMed ID:
38678966
Abstract
Mitochondrial dysmorphology/dysfunction follow global cerebral ischemia-reperfusion (GCI/R) injury, leading to neuronal death. Our previous researches demonstrated that Levodopa (L-DOPA) improves learning and memory impairment in GCI/R rats by increasing synaptic plasticity of hippocampal neurons. This study investigates if L-DOPA, used in Parkinson's disease treatment, alleviates GCI/R-induced cell death by enhancing mitochondrial quality. Metabolomics and transcriptomic results showed that GCI/R damage affected the Tricarboxylic acid (TCA) cycle in the hippocampus. The results of this study show that L-DOPA stabilized mitochondrial membrane potential and ultrastructure in hippocampus of GCI/R rats, increased dopamine level in hippocampus, decreased succinic acid level, and stabilized Ca
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4
Total citations:
4
Citations from 2024:
4
(100%)
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GOST
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Wang W. et al. L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury // Biomedicine and Pharmacotherapy. 2024. Vol. 175. p. 116664.
GOST all authors (up to 50)
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Wang W., Zhao J., Li Z., Kang X., Smirnova E. A., Liu L., Yu Y. L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury // Biomedicine and Pharmacotherapy. 2024. Vol. 175. p. 116664.
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TY - JOUR
DO - 10.1016/j.biopha.2024.116664
UR - https://linkinghub.elsevier.com/retrieve/pii/S0753332224005481
TI - L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury
T2 - Biomedicine and Pharmacotherapy
AU - Wang, Wenzhu
AU - Zhao, Jingyu
AU - Li, Zihan
AU - Kang, Xiaoyu
AU - Smirnova, Elena A
AU - Liu, Lixu
AU - Yu, Yan
PY - 2024
DA - 2024/06/01
PB - Elsevier
SP - 116664
VL - 175
PMID - 38678966
SN - 0753-3322
SN - 1950-6007
ER -
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BibTex (up to 50 authors)
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@article{2024_Wang,
author = {Wenzhu Wang and Jingyu Zhao and Zihan Li and Xiaoyu Kang and Elena A Smirnova and Lixu Liu and Yan Yu},
title = {L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury},
journal = {Biomedicine and Pharmacotherapy},
year = {2024},
volume = {175},
publisher = {Elsevier},
month = {jun},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0753332224005481},
pages = {116664},
doi = {10.1016/j.biopha.2024.116664}
}
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