Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses
Scott A. Allen
1
,
Brian A. Johns
1
,
Kristjan S Gudmundsson
1
,
George A Freeman
1
,
F.Leslie Boyd
1
,
Connie H Sexton
2
,
Dean W Selleseth
2
,
Katrina L. Creech
2
,
Kelly R Moniri
2
1
Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA
|
2
Department of Virology, GlaxoSmithKline Research and Development, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA
|
Тип публикации: Journal Article
Дата публикации: 2006-02-01
scimago Q2
wos Q1
БС1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
16213142
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A novel series of potent C-6 substituted pyrazolo[1,5-a]pyridine inhibitors of herpes simplex viruses has been identified. A synthetic methodology was developed involving functionalization of a C-6 trifluoromethyl pyrazolo[1,5-a]pyridine to allow facile access to a diverse set of analogues from common late stage intermediates. The expansion of the SAR of this series at the 6 position allows for modifications to developability parameters such as clogP, while maintaining potency comparable to acyclovir.
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Allen S. A. et al. Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses // Bioorganic and Medicinal Chemistry. 2006. Vol. 14. No. 4. pp. 944-954.
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Allen S. A., Johns B. A., Gudmundsson K. S., Freeman G. A., Boyd F., Sexton C. H., Selleseth D. W., Creech K. L., Moniri K. R. Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses // Bioorganic and Medicinal Chemistry. 2006. Vol. 14. No. 4. pp. 944-954.
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TY - JOUR
DO - 10.1016/j.bmc.2005.09.015
UR - https://doi.org/10.1016/j.bmc.2005.09.015
TI - Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses
T2 - Bioorganic and Medicinal Chemistry
AU - Allen, Scott A.
AU - Johns, Brian A.
AU - Gudmundsson, Kristjan S
AU - Freeman, George A
AU - Boyd, F.Leslie
AU - Sexton, Connie H
AU - Selleseth, Dean W
AU - Creech, Katrina L.
AU - Moniri, Kelly R
PY - 2006
DA - 2006/02/01
PB - Elsevier
SP - 944-954
IS - 4
VL - 14
PMID - 16213142
SN - 0968-0896
SN - 1464-3391
ER -
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@article{2006_Allen,
author = {Scott A. Allen and Brian A. Johns and Kristjan S Gudmundsson and George A Freeman and F.Leslie Boyd and Connie H Sexton and Dean W Selleseth and Katrina L. Creech and Kelly R Moniri},
title = {Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses},
journal = {Bioorganic and Medicinal Chemistry},
year = {2006},
volume = {14},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmc.2005.09.015},
number = {4},
pages = {944--954},
doi = {10.1016/j.bmc.2005.09.015}
}
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MLA
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Allen, Scott A., et al. “Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.” Bioorganic and Medicinal Chemistry, vol. 14, no. 4, Feb. 2006, pp. 944-954. https://doi.org/10.1016/j.bmc.2005.09.015.