Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents
2
Discovery & Development Laboratory I, Hanno Research Center, Taiho Pharmaceutical Co., Ltd, 1-27 Misugidai, Hanno, Saitama 357, Japan
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Publication type: Journal Article
Publication date: 2010-08-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
20609590
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers. These synthesized dimers exhibited binding affinity to the N-terminal domain of Hsp90, cytotoxicity, and client degradation activity although these activities were comparative or weak comparable with that of the parent compound.
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SEKIGUCHI H. et al. Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents // Bioorganic and Medicinal Chemistry. 2010. Vol. 18. No. 15. pp. 5732-5737.
GOST all authors (up to 50)
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SEKIGUCHI H., MURANAKA K., OSADA A., Ichikawa S., Matsuda A. Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents // Bioorganic and Medicinal Chemistry. 2010. Vol. 18. No. 15. pp. 5732-5737.
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RIS
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TY - JOUR
DO - 10.1016/j.bmc.2010.05.075
UR - https://doi.org/10.1016/j.bmc.2010.05.075
TI - Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents
T2 - Bioorganic and Medicinal Chemistry
AU - SEKIGUCHI, Hironori
AU - MURANAKA, Kazuhiro
AU - OSADA, AKIKO
AU - Ichikawa, Satoshi
AU - Matsuda, Akira
PY - 2010
DA - 2010/08/01
PB - Elsevier
SP - 5732-5737
IS - 15
VL - 18
PMID - 20609590
SN - 0968-0896
SN - 1464-3391
ER -
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BibTex (up to 50 authors)
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@article{2010_SEKIGUCHI,
author = {Hironori SEKIGUCHI and Kazuhiro MURANAKA and AKIKO OSADA and Satoshi Ichikawa and Akira Matsuda},
title = {Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents},
journal = {Bioorganic and Medicinal Chemistry},
year = {2010},
volume = {18},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmc.2010.05.075},
number = {15},
pages = {5732--5737},
doi = {10.1016/j.bmc.2010.05.075}
}
Cite this
MLA
Copy
SEKIGUCHI, Hironori, et al. “Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.” Bioorganic and Medicinal Chemistry, vol. 18, no. 15, Aug. 2010, pp. 5732-5737. https://doi.org/10.1016/j.bmc.2010.05.075.