The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents
Тип публикации: Journal Article
Дата публикации: 2009-08-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
19539467
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A series of non-basic building blocks was synthesized and introduced to the C7 position of the quinolone nucleus 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid to afford the corresponding fluoroquinolones in 46-85% yield. The antibacterial activity of these new fluoroquinolones was evaluated using a standard broth microdilution technique. The sulfur-containing quinolone, 7-(2-thia-5-azabicyclo[2.2.1]heptan-5-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid exhibited a superior antibacterial activity against quinolone-susceptible and multidrug-resistant strains in comparison with the clinically used fluoroquinolones ciprofloxacin and vancomycin, especially to the Streptococcus pneumonia and multidrug-resistant S. pneumonia clinical isolates.
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Huang X. et al. The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 15. pp. 4130-4133.
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Huang X., Chen D., Wu N., Zhang A., Jia Z., Li X. The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 15. pp. 4130-4133.
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TY - JOUR
DO - 10.1016/j.bmcl.2009.06.006
UR - https://doi.org/10.1016/j.bmcl.2009.06.006
TI - The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Huang, Xiaoguang
AU - Chen, Dongliang
AU - Wu, Ning
AU - Zhang, Aiqin
AU - Jia, Zhenhua
AU - Li, Xingshu
PY - 2009
DA - 2009/08/01
PB - Elsevier
SP - 4130-4133
IS - 15
VL - 19
PMID - 19539467
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2009_Huang,
author = {Xiaoguang Huang and Dongliang Chen and Ning Wu and Aiqin Zhang and Zhenhua Jia and Xingshu Li},
title = {The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2009},
volume = {19},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2009.06.006},
number = {15},
pages = {4130--4133},
doi = {10.1016/j.bmcl.2009.06.006}
}
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MLA
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Huang, Xiaoguang, et al. “The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents.” Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 15, Aug. 2009, pp. 4130-4133. https://doi.org/10.1016/j.bmcl.2009.06.006.