1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
Michael B. Tollefson
1
,
Brad A Acker
1
,
E J Jacobsen
1
,
Robert O Hughes
1
,
John Walker
1
,
David Fox
2
,
Michael A Palmer
2
,
Sandra K. Freeman
1
,
Y. Yu
1
,
Brian R. Bond
1
1
Pfizer Global Research and Development, 700 Chesterfield Parkway, Chesterfield, MO 63017, United States
|
2
Pfizer Global Research & Development, Sandwich, Kent CT13 9NJ, United Kingdom.
|
Тип публикации: Journal Article
Дата публикации: 2010-05-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
20400309
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
1H-Pyrazolo[4,3-d]pyrimidines were previously disclosed as a potent second generation class of phosphodiesterase 5 (PDE5) inhibitors. This work explores the advancement of more selective and potent PDE5 inhibitors resulting from the substitution of 2-(2,2,2-trifluoroethoxy)ethyl at the 1 position in the so-called alkoxy pocket.
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Tollefson M. B. et al. 1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 10. pp. 3125-3128.
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Tollefson M. B., Acker B. A., Jacobsen E. J., Hughes R. O., Walker J., Fox D., Palmer M. A., Freeman S. K., Yu Y., Bond B. R. 1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 10. pp. 3125-3128.
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TY - JOUR
DO - 10.1016/j.bmcl.2010.03.106
UR - https://doi.org/10.1016/j.bmcl.2010.03.106
TI - 1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Tollefson, Michael B.
AU - Acker, Brad A
AU - Jacobsen, E J
AU - Hughes, Robert O
AU - Walker, John
AU - Fox, David
AU - Palmer, Michael A
AU - Freeman, Sandra K.
AU - Yu, Y.
AU - Bond, Brian R.
PY - 2010
DA - 2010/05/01
PB - Elsevier
SP - 3125-3128
IS - 10
VL - 20
PMID - 20400309
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2010_Tollefson,
author = {Michael B. Tollefson and Brad A Acker and E J Jacobsen and Robert O Hughes and John Walker and David Fox and Michael A Palmer and Sandra K. Freeman and Y. Yu and Brian R. Bond},
title = {1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2010},
volume = {20},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bmcl.2010.03.106},
number = {10},
pages = {3125--3128},
doi = {10.1016/j.bmcl.2010.03.106}
}
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MLA
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Tollefson, Michael B., et al. “1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 10, May. 2010, pp. 3125-3128. https://doi.org/10.1016/j.bmcl.2010.03.106.