Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents
Publication type: Journal Article
Publication date: 2010-08-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
20598531
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of novel 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs (3) have been synthesized under microwave irradiation and conventional heating methods. These analogs were evaluated for in vitro cytotoxicity against a panel of 57 human tumor cell lines. Compound 3o had GI(50) values of 190 nM and 750 nM against A549/ATTC non-small cell lung cancer and LOX IMVI melanoma cell lines, respectively, and both 3n and 3o exhibited GI(50) values ranging from 2 to 5 microM against CCRF-CEM, HL-60(TB), K-562, MOLT-4, and RPMI-8226 leukemia cell lines. These results indicate that N-4-methoxybenzyl-3-hydroxy-(2-imino-3-methyl-5-oxo-4-yl)indolin-2-one analogs may be useful leads for anticancer drug development.
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Total citations:
34
Citations from 2024:
3
(8.82%)
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GOST
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Penthala N. R. et al. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 15. pp. 4468-4471.
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Penthala N. R., Yerramreddy T. R., Madadi N. R., Crooks P. A. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 15. pp. 4468-4471.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2010.06.042
UR - https://doi.org/10.1016/j.bmcl.2010.06.042
TI - Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Penthala, Narsimha R.
AU - Yerramreddy, Thirupathi Reddy
AU - Madadi, Nikhil Reddy
AU - Crooks, Peter A.
PY - 2010
DA - 2010/08/01
PB - Elsevier
SP - 4468-4471
IS - 15
VL - 20
PMID - 20598531
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{2010_Penthala,
author = {Narsimha R. Penthala and Thirupathi Reddy Yerramreddy and Nikhil Reddy Madadi and Peter A. Crooks},
title = {Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2010},
volume = {20},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2010.06.042},
number = {15},
pages = {4468--4471},
doi = {10.1016/j.bmcl.2010.06.042}
}
Cite this
MLA
Copy
Penthala, Narsimha R., et al. “Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.” Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 15, Aug. 2010, pp. 4468-4471. https://doi.org/10.1016/j.bmcl.2010.06.042.