N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae
Brad Johnson
1
,
Rachel Steadman
2
,
Krista D Patefield
3
,
Jeffrey J Bunker
3
,
Audrey L Atkin
4
,
Patrick H. Dussault
5
4
Biological Sciences
Publication type: Journal Article
Publication date: 2011-04-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
21421312
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.
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Johnson B. et al. N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 8. pp. 2351-2353.
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Johnson B., Steadman R., Patefield K. D., Bunker J. J., Atkin A. L., Dussault P. H. N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 8. pp. 2351-2353.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2011.02.081
UR - https://doi.org/10.1016/j.bmcl.2011.02.081
TI - N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Johnson, Brad
AU - Steadman, Rachel
AU - Patefield, Krista D
AU - Bunker, Jeffrey J
AU - Atkin, Audrey L
AU - Dussault, Patrick H.
PY - 2011
DA - 2011/04/01
PB - Elsevier
SP - 2351-2353
IS - 8
VL - 21
PMID - 21421312
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{2011_Johnson,
author = {Brad Johnson and Rachel Steadman and Krista D Patefield and Jeffrey J Bunker and Audrey L Atkin and Patrick H. Dussault},
title = {N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2011},
volume = {21},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bmcl.2011.02.081},
number = {8},
pages = {2351--2353},
doi = {10.1016/j.bmcl.2011.02.081}
}
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MLA
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Johnson, Brad, et al. “N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae.” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 8, Apr. 2011, pp. 2351-2353. https://doi.org/10.1016/j.bmcl.2011.02.081.