Synthesis and transfection activity of novel galactosylated polycationic lipid
Michael Maslov
1
,
D A Medvedeva
2
,
D A Rapoport
2
,
R N Serikov
2
,
N G Morozova
3
,
G A Serebrennikova
3
,
Valentin V. Vlassov
2
,
Publication type: Journal Article
Publication date: 2011-05-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
21463941
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
In this study, we synthesized a new galactosylated cationic lipid and investigated its biological activity. The structure of lipid combines both spermine residue for DNA compaction and galactose moiety for the improvement of aggregation behavior of lipoplexes. Lipid was low toxic for different mammalian cells, and was able both to compact plasmid DNA and to mediate cellular accumulation of various nucleic acids (ODN, pDNA and siRNA) exhibiting biological activity (transgene expression, gene silencing).
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GOST
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Maslov M. et al. Synthesis and transfection activity of novel galactosylated polycationic lipid // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 10. pp. 2937-2940.
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Maslov M., Medvedeva D. A., Rapoport D. A., Serikov R. N., Morozova N. G., Serebrennikova G. A., Vlassov V. V., Зенкова М. А. Synthesis and transfection activity of novel galactosylated polycationic lipid // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 10. pp. 2937-2940.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2011.03.056
UR - https://linkinghub.elsevier.com/retrieve/pii/S0960894X11003751
TI - Synthesis and transfection activity of novel galactosylated polycationic lipid
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Maslov, Michael
AU - Medvedeva, D A
AU - Rapoport, D A
AU - Serikov, R N
AU - Morozova, N G
AU - Serebrennikova, G A
AU - Vlassov, Valentin V.
AU - Зенкова, М. А.
PY - 2011
DA - 2011/05/01
PB - Elsevier
SP - 2937-2940
IS - 10
VL - 21
PMID - 21463941
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Maslov,
author = {Michael Maslov and D A Medvedeva and D A Rapoport and R N Serikov and N G Morozova and G A Serebrennikova and Valentin V. Vlassov and М. А. Зенкова},
title = {Synthesis and transfection activity of novel galactosylated polycationic lipid},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2011},
volume = {21},
publisher = {Elsevier},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0960894X11003751},
number = {10},
pages = {2937--2940},
doi = {10.1016/j.bmcl.2011.03.056}
}
Cite this
MLA
Copy
Maslov, Michael, et al. “Synthesis and transfection activity of novel galactosylated polycationic lipid.” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 10, May. 2011, pp. 2937-2940. https://linkinghub.elsevier.com/retrieve/pii/S0960894X11003751.
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