Bioorganic and Medicinal Chemistry Letters, volume 22, issue 8, pages 2973-2975
Unambiguous structure of atractyloside and carboxyatractyloside
Jean-Frederic Sanchez
1
,
Brice Kauffmann
2
,
Axelle Grelard
3
,
Corinne Sanchez
4
,
Véronique Trézéguet
4
,
Ivan Huc
3
,
Guy J.-M. Lauquin
4
4
CNRS, IBGC, UMR 5095, Laboratoire de Physiologie Moléculaire et Cellulaire, 1 rue Camille Saint-Saëns, F-33077 Bordeaux-cedex, France
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Publication type: Journal Article
Publication date: 2012-04-01
scimago Q2
SJR: 0.508
CiteScore: 5.7
Impact factor: 2.5
ISSN: 0960894X, 14643405
PubMed ID:
22425567
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Atractyloside (ATR) was characterized in 1868 and until now structural studies on diterpenic moiety had been done through the characterization of ATR derivatives; while the glycosidic moiety seemed to be a β-D-glucopyranose a recent crystal structure of the mitochondrial ATP/ADP carrier in complex with CATR showed an α-D-glucopyranose. We decided to re-examine the ATR and CATR structures by crystallographic study of ATR.
Found
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