Bioorganic and Medicinal Chemistry Letters

, volume 22 , issue 14 , pages 4665-4667

Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents

Richa Goel ¹

Vishal Sharma ¹

Abhishek Budhiraja ²

Mohan Paul S. Ishar ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India |

ISF College of Pharmacy, Moga 142001, Punjab, India |

Publication type: Journal Article

Publication date: 2012-07-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2012.05.086

Copy DOI

PubMed ID: 22721712

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

An efficient synthesis of novel antifungal 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones (10a-j) through 1,3-dipolar cycloaddition of all carbon 1,3-dipole (7) with substituted 3-formylchromones (8a-j) has been developed. The synthesized compounds were characterized spectroscopically and evaluated in vitro for antifungal activity against various strains. Some of the compounds 10b, 10d and 10i exhibit significant inhibitory potential against Aspergillus niger, Saccahromyces cerevisiae and Candida albicans.

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GOST |

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GOST Copy

Goel R. et al. Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 14. pp. 4665-4667.

GOST all authors (up to 50) Copy

Goel R., Sharma V., Budhiraja A., Ishar M. P. S. Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 14. pp. 4665-4667.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2012.05.086

UR - https://doi.org/10.1016/j.bmcl.2012.05.086

TI - Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Goel, Richa

AU - Sharma, Vishal

AU - Budhiraja, Abhishek

AU - Ishar, Mohan Paul S.

PY - 2012

DA - 2012/07/01

PB - Elsevier

SP - 4665-4667

IS - 14

VL - 22

PMID - 22721712

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2012_Goel,

author = {Richa Goel and Vishal Sharma and Abhishek Budhiraja and Mohan Paul S. Ishar},

title = {Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2012},

volume = {22},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016/j.bmcl.2012.05.086},

number = {14},

pages = {4665--4667},

doi = {10.1016/j.bmcl.2012.05.086}

}

MLA

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MLA Copy

Goel, Richa, et al. “Synthesis and evaluation of novel 3a,9a-dihydro-1-ethoxycarbonyl-1-cyclopenteno[5,4-b]benzopyran-4-ones as antifungal agents.” Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 14, Jul. 2012, pp. 4665-4667. https://doi.org/10.1016/j.bmcl.2012.05.086.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)