Carbohydrate Polymers

, volume 101 , pages 1087-1093

Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity

A V Volodko ¹

V.N. Davydova ¹

E.A. Chusovitin ²

I V Sorokina ³

M P Dolgikh ³

Tatjana Genrihovna Tolstikova ³

S A Balagan ^{4, 5}

N. G. Galkin ^{4, 5}

I M Yermak ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

G.B Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Prospect 100 let Vladivostoku 159, Vladivostok 690022, Russia. |

Institute of Automation and Control Processes of Far Eastern Branch of Russian Academy of Sciences, Radio St.5, Vladivostok 690041, Russia |

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentjev Ave. 9, Novosibirsk 630090, Russia |

⁴

Far Eastern Federal University, 8 Suhanova Str., Vladivostok 690950, Russia |

⁵

Institute of Automation and Control Processes of Far Eastern Branch of Russian Academy of Sciences, Radio St. 5, Vladivostok 690041, Russia |

Publication type: Journal Article

Publication date: 2014-01-01

Elsevier

Carbohydrate Polymers

scimago Q1

wos Q1

SJR: 2.004

CiteScore: 24.0

Impact factor: 12.5

ISSN: 01448617, 18791344

DOI: 10.1016/j.carbpol.2013.10.049

Copy DOI

PubMed ID: 24299878

Materials Chemistry

Organic Chemistry

Polymers and Plastics

Abstract

The soluble polyelectrolyte complexes (PEC) κ-carrageenan (κ-CG):chitosan was obtained. Binding constant value (2.11 × 10(7)mol(-1)) showed high affinity of κ-CG to chitosan. The complex formation of κ-CG:chitosan 1:10 and 10:1 w/w was shown by centrifugation in a Percoll gradient. Using atomic force microscopy we showed that the supramolecular structure of the complexes is different from each other and from the macromolecular structure of the initial polysaccharides. The gastroprotective and anti-ulcerogenic effect of κ-CG, chitosan and their complexes was investigated on the model of stomach ulcers induced by indometacin in rats. PEC κ-CG:chitosan have gastroprotective properties which depend on their composition. Complex κ-CG:chitosan 1:10 w/w possesses higher gastroprotective activity than the complex 10:1 w/w. These results suggest that the gastroprotective effect of complexes can be associated with their protective layer on the surface of the mucous membrane of a stomach, which avoids a direct contact with the ulcerogenic agent.

Found

7 citations

Davydova Viktoriya

PhD in Chemistry

41 publications, 830 citations, 14 reviews

h-index: 16

G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences

Physical chemistry of polymers

Polyelectrolyte complexes

Polysaccharides of red algae

7 citations

Ermak I

🥼 🤝

DSc in Chemistry

88 publications, 1 733 citations

h-index: 26

G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences

6 citations

Volod'ko Aleksandra

🥼 🤝

PhD in Chemistry

20 publications, 383 citations

h-index: 12

G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences

Research interests

3D bioprinting

Atomic force microscopy

Drug delivery

Isolation and study of polysaccharides

Mechanics and rheology of polymers

Polyelectrolyte complexes

1 citation

Kravchenko Anna

PhD in Chemistry

26 publications, 422 citations, 1 review

h-index: 13

G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences

Research interests

Bioorganic chemistry

Polymer Chemistry

Polysaccharides of red algae

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GOST Copy

Volodko A. V. et al. Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity // Carbohydrate Polymers. 2014. Vol. 101. pp. 1087-1093.

GOST all authors (up to 50) Copy

Volodko A. V., Davydova V., Chusovitin E., Sorokina I. V., Dolgikh M. P., Tolstikova T. G., Balagan S. A., Galkin N. G., Yermak I. M. Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity // Carbohydrate Polymers. 2014. Vol. 101. pp. 1087-1093.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.carbpol.2013.10.049

UR - https://doi.org/10.1016/j.carbpol.2013.10.049

TI - Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity

T2 - Carbohydrate Polymers

AU - Volodko, A V

AU - Davydova, V.N.

AU - Chusovitin, E.A.

AU - Sorokina, I V

AU - Dolgikh, M P

AU - Tolstikova, Tatjana Genrihovna

AU - Balagan, S A

AU - Galkin, N. G.

AU - Yermak, I M

PY - 2014

DA - 2014/01/01

PB - Elsevier

SP - 1087-1093

VL - 101

PMID - 24299878

SN - 0144-8617

SN - 1879-1344

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2014_Volodko,

author = {A V Volodko and V.N. Davydova and E.A. Chusovitin and I V Sorokina and M P Dolgikh and Tatjana Genrihovna Tolstikova and S A Balagan and N. G. Galkin and I M Yermak},

title = {Soluble chitosan–carrageenan polyelectrolyte complexes and their gastroprotective activity},

journal = {Carbohydrate Polymers},

year = {2014},

volume = {101},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.carbpol.2013.10.049},

pages = {1087--1093},

doi = {10.1016/j.carbpol.2013.10.049}

}

Publisher

Elsevier

Journal

Carbohydrate Polymers

scimago Q1

wos Q1

SJR

2.004

CiteScore

24.0

Impact factor

12.5

ISSN

01448617 (Print)

18791344 (Electronic)

Labs

Laboratory of molecular foundations of antibacterial immunity

Profiles