Elsevier
Chinese Chemical Letters
,  том 24 ,  издание 12 ,  страницы 1118-1122

Synthesis of the major isomers of Aprepitant and Fosaprepitant

Тип публикации: Journal Article
Дата публикации: 2013-12-01
Elsevier
scimago Q1
wos Q1
БС1
SJR: 1.677
CiteScore: 15.7
Impact factor: 8.9
ISSN: 10018417, 18785964
General Chemistry
Краткое описание
The synthesis of two isomers of Aprepitant (APT) and three isomers of Fosaprepitant (FPT), crucial components for quality control in manufacturing, is described. Herein, three chiral centers in the isomers of Aprepitant are established in high yield by induced crystallization and chiral reduction. Additionally, the isomers of Aprepitant are utilized to synthesize the isomers of Fosaprepitant with the same stereochemistry. All the target compounds were confirmed by elemental analyses, IR, NMR and MS data analysis.
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ГОСТ |
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ГОСТ Скопировать
Wan W. L. et al. Synthesis of the major isomers of Aprepitant and Fosaprepitant // Chinese Chemical Letters. 2013. Vol. 24. No. 12. pp. 1118-1122.
ГОСТ со всеми авторами (до 50) Скопировать
Wan W. L., He Y., Guan M., Li X., Xu C., Wu Y. Synthesis of the major isomers of Aprepitant and Fosaprepitant // Chinese Chemical Letters. 2013. Vol. 24. No. 12. pp. 1118-1122.
RIS |
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TY - JOUR
DO - 10.1016/j.cclet.2013.07.017
UR - https://doi.org/10.1016/j.cclet.2013.07.017
TI - Synthesis of the major isomers of Aprepitant and Fosaprepitant
T2 - Chinese Chemical Letters
AU - Wan, Wei Li
AU - He, Yun
AU - Guan, Mei
AU - Li, Xiao-Long
AU - Xu, Cheng
AU - Wu, Yong
PY - 2013
DA - 2013/12/01
PB - Elsevier
SP - 1118-1122
IS - 12
VL - 24
SN - 1001-8417
SN - 1878-5964
ER -
BibTex |
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@article{2013_Wan,
author = {Wei Li Wan and Yun He and Mei Guan and Xiao-Long Li and Cheng Xu and Yong Wu},
title = {Synthesis of the major isomers of Aprepitant and Fosaprepitant},
journal = {Chinese Chemical Letters},
year = {2013},
volume = {24},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.cclet.2013.07.017},
number = {12},
pages = {1118--1122},
doi = {10.1016/j.cclet.2013.07.017}
}
MLA
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Wan, Wei Li, et al. “Synthesis of the major isomers of Aprepitant and Fosaprepitant.” Chinese Chemical Letters, vol. 24, no. 12, Dec. 2013, pp. 1118-1122. https://doi.org/10.1016/j.cclet.2013.07.017.