Chinese Chemical Letters

, volume 26 , issue 10 , pages 1315-1318

Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives

Feng Yun Li ¹

Xiaofeng Guo ¹

Zhijin Fan ¹

Yuan Zhang ¹

Guang Ning Zong ¹

Xiaolin Qian ¹

Liu Yong Ma ¹

Lei Chen ¹

Yujie Zhu ¹

Tatiana Kalinina ²

Yury Yu. Morzherin ²

Nataliya P. Belskaya ²

Hide authors affiliations Show authors affiliations: 2 affiliations

State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, China.

Nankai University

Collaborative Innovation Center of Chemical Science and Engineering Tianjin

The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia |

Publication type: Journal Article

Publication date: 2015-10-01

Elsevier

Chinese Chemical Letters

scimago Q1

wos Q1

SJR: 1.677

CiteScore: 15.7

Impact factor: 8.9

ISSN: 10018417, 18785964

DOI: 10.1016/j.cclet.2015.05.040

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General Chemistry

Abstract

A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, 13C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 μg/mL, compounds 4b and 4i exhibited over 50% activity against six fungi tested. Most compounds showed good activity against TMV with different models in vivo at 100 μg/mL. Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control.

Found

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Minin Artem

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110 publications, 856 citations, 14 reviews

h-index: 16

M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences

Ural Federal University

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GOST |

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GOST Copy

Li F. Y. et al. Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives // Chinese Chemical Letters. 2015. Vol. 26. No. 10. pp. 1315-1318.

GOST all authors (up to 50) Copy

Li F. Y., Guo X., Fan Z., Zhang Y., Zong G. N., Qian X., Ma L. Y., Chen L., Zhu Y., Kalinina T., Morzherin Y. Y., Belskaya N. P. Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives // Chinese Chemical Letters. 2015. Vol. 26. No. 10. pp. 1315-1318.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.cclet.2015.05.040

UR - https://doi.org/10.1016/j.cclet.2015.05.040

TI - Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives

T2 - Chinese Chemical Letters

AU - Li, Feng Yun

AU - Guo, Xiaofeng

AU - Fan, Zhijin

AU - Zhang, Yuan

AU - Zong, Guang Ning

AU - Qian, Xiaolin

AU - Ma, Liu Yong

AU - Chen, Lei

AU - Zhu, Yujie

AU - Kalinina, Tatiana

AU - Morzherin, Yury Yu.

AU - Belskaya, Nataliya P.

PY - 2015

DA - 2015/10/01

PB - Elsevier

SP - 1315-1318

IS - 10

VL - 26

SN - 1001-8417

SN - 1878-5964

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2015_Li,

author = {Feng Yun Li and Xiaofeng Guo and Zhijin Fan and Yuan Zhang and Guang Ning Zong and Xiaolin Qian and Liu Yong Ma and Lei Chen and Yujie Zhu and Tatiana Kalinina and Yury Yu. Morzherin and Nataliya P. Belskaya},

title = {Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives},

journal = {Chinese Chemical Letters},

year = {2015},

volume = {26},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.cclet.2015.05.040},

number = {10},

pages = {1315--1318},

doi = {10.1016/j.cclet.2015.05.040}

}

MLA

Cite this

MLA Copy

Li, Feng Yun, et al. “Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives.” Chinese Chemical Letters, vol. 26, no. 10, Oct. 2015, pp. 1315-1318. https://doi.org/10.1016/j.cclet.2015.05.040.

Publisher

Elsevier

Journal

Chinese Chemical Letters

scimago Q1

wos Q1

SJR

1.677

CiteScore

15.7

Impact factor

8.9

ISSN

10018417 (Print)

18785964