Understanding the Odd Science of Aging
Publication type: Journal Article
Publication date: 2005-02-25
scimago Q1
wos Q1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
15734677
General Biochemistry, Genetics and Molecular Biology
Abstract
Evolutionary considerations suggest aging is caused not by active gene programming but by evolved limitations in somatic maintenance, resulting in a build-up of damage. Ecological factors such as hazard rates and food availability influence the trade-offs between investing in growth, reproduction, and somatic survival, explaining why species evolved different life spans and why aging rate can sometimes be altered, for example, by dietary restriction. To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay.
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Metrics
1.6k
Total citations:
1558
Citations from 2025:
87
(5.59%)
Cite this
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BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.cell.2005.01.027
UR - https://doi.org/10.1016/j.cell.2005.01.027
TI - Understanding the Odd Science of Aging
T2 - Cell
AU - Kirkwood, Thomas
PY - 2005
DA - 2005/02/25
PB - Elsevier
SP - 437-447
IS - 4
VL - 120
PMID - 15734677
SN - 0092-8674
SN - 1097-4172
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Kirkwood,
author = {Thomas Kirkwood},
title = {Understanding the Odd Science of Aging},
journal = {Cell},
year = {2005},
volume = {120},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.cell.2005.01.027},
number = {4},
pages = {437--447},
doi = {10.1016/j.cell.2005.01.027}
}
Cite this
MLA
Copy
Kirkwood, Thomas B.L. “Understanding the Odd Science of Aging.” Cell, vol. 120, no. 4, Feb. 2005, pp. 437-447. https://doi.org/10.1016/j.cell.2005.01.027.