Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
Daniel E. Stange
1, 2
,
Bon-Kyoung Koo
2, 3
,
Meritxell Huch
4
,
Greg Sibbel
5
,
O. Basak
4
,
Anna Lyubimova
2, 6
,
Pekka Kujala
7
,
Sina Bartfeld
4
,
Jan Koster
8
,
Jessica H Geahlen
5
,
PETER E. PETERS
7
,
Johan H. van Es
4
,
Marc van de Wetering
4
,
Jason Mills
5
,
2
4
6
Publication type: Journal Article
Publication date: 2013-10-10
scimago Q1
wos Q1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
24120136
General Biochemistry, Genetics and Molecular Biology
Abstract
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base. The isthmus is therefore generally viewed as the stem cell zone. We find that the stem cell marker Troy is expressed at the gland base by a small subpopulation of fully differentiated chief cells. By lineage tracing with a Troy-eGFP-ires-CreERT2 allele, single marked chief cells are shown to generate entirely labeled gastric units over periods of months. This phenomenon accelerates upon tissue damage. Troy(+) chief cells can be cultured to generate long-lived gastric organoids. Troy marks a specific subset of chief cells that display plasticity in that they are capable of replenishing entire gastric units, essentially serving as quiescent "reserve" stem cells. These observations challenge the notion that stem cell hierarchies represent a "one-way street."
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451
Total citations:
451
Citations from 2024:
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(11.08%)
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GOST
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Stange D. E. et al. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium // Cell. 2013. Vol. 155. No. 2. pp. 357-368.
GOST all authors (up to 50)
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Stange D. E., Koo B., Huch M., Sibbel G., Basak O., Lyubimova A., Kujala P., Bartfeld S., Koster J., Geahlen J. H., PETERS P. E., van Es J. H., van de Wetering M., Mills J., Clevers H. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium // Cell. 2013. Vol. 155. No. 2. pp. 357-368.
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RIS
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TY - JOUR
DO - 10.1016/j.cell.2013.09.008
UR - https://doi.org/10.1016/j.cell.2013.09.008
TI - Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
T2 - Cell
AU - Stange, Daniel E.
AU - Koo, Bon-Kyoung
AU - Huch, Meritxell
AU - Sibbel, Greg
AU - Basak, O.
AU - Lyubimova, Anna
AU - Kujala, Pekka
AU - Bartfeld, Sina
AU - Koster, Jan
AU - Geahlen, Jessica H
AU - PETERS, PETER E.
AU - van Es, Johan H.
AU - van de Wetering, Marc
AU - Mills, Jason
AU - Clevers, Hans
PY - 2013
DA - 2013/10/10
PB - Elsevier
SP - 357-368
IS - 2
VL - 155
PMID - 24120136
SN - 0092-8674
SN - 1097-4172
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Stange,
author = {Daniel E. Stange and Bon-Kyoung Koo and Meritxell Huch and Greg Sibbel and O. Basak and Anna Lyubimova and Pekka Kujala and Sina Bartfeld and Jan Koster and Jessica H Geahlen and PETER E. PETERS and Johan H. van Es and Marc van de Wetering and Jason Mills and Hans Clevers},
title = {Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium},
journal = {Cell},
year = {2013},
volume = {155},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.cell.2013.09.008},
number = {2},
pages = {357--368},
doi = {10.1016/j.cell.2013.09.008}
}
Cite this
MLA
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Stange, Daniel E., et al. “Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium.” Cell, vol. 155, no. 2, Oct. 2013, pp. 357-368. https://doi.org/10.1016/j.cell.2013.09.008.