Integrated Genomic Characterization of Papillary Thyroid Carcinoma
Nishant Agrawal
,
Rehan Akbani
,
B Arman Aksoy
,
Adrian Ally
,
Harindra Arachchi
,
Sylvia L. Asa
,
James R. Auman
,
Miruna Balasundaram
,
Saianand Balu
,
STEPHEN B. BAYLIN
,
Madhusmita Behera
,
Brady Bernard
,
R. Beroukhim
,
Justin A. Bishop
,
Aaron D Black
,
Tom Bodenheimer
,
Lori Boice
,
Moiz S Bootwalla
,
Jay Bowen
,
Reanne Bowlby
,
Christopher A. Bristow
,
Robin Brookens
,
Denise Brooks
,
Robert Bryant
,
Elizabeth Buda
,
Yaron S N Butterfield
,
Tobias Carling
,
Rebecca Carlsen
,
Sally E. Carty
,
Timothy A Chan
,
Amy Y Chen
,
Andrew D. Cherniack
,
Dorothy Cheung
,
Lynda Chin
,
Juok Cho
,
Andy Chu
,
Eric Chuah
,
Kristian Cibulskis
,
G. Ciriello
,
Amanda Clarke
,
Gary L. Clayman
,
Leslie Cope
,
John A Copland
,
Kyle Covington
,
Ludmila Danilova
,
Tanja Davidsen
,
John A Demchok
,
Daniel Dicara
,
Noreen Dhalla
,
Rajiv Dhir
,
Sheliann S Dookran
,
Gideon Dresdner
,
Jonathan Eldridge
,
Greg Eley
,
Adel K. El-Naggar
,
Stephanie Eng
,
JAMES FAGIN
,
T. R. Fennell
,
Paul M. Brennan
,
Sheila Fisher
,
Scott Frazer
,
Jessica Frick
,
Stacey B. Gabriel
,
Ian Ganly
,
Jianjiong Gao
,
Levi A. Garraway
,
J. Gastier-Foster
,
Gad Getz
,
Nils Gehlenborg
,
Ronald Ghossein
,
Richard A. Gibbs
,
Thomas P. Giordano
,
Karen Gomez Hernandez
,
Jonna Grimsby
,
Benjamin Gross
,
Ranabir Guin
,
Angela Hadjipanayis
,
Hollie A. Harper
,
D. S. Hayes
,
D Heiman
,
James G. Herman
,
Matan Hofree
,
Robert A Holt
,
Alan P Hoyle
,
Franklin W. Huang
,
Mei Huang
,
Carolyn M. Hutter
,
Lisa Iype
,
Anders Jacobsen
,
Stuart R Jefferys
,
Corbin D. Jones
,
Steve M. R. Jones
,
Katayoon Kasaian
,
Electron Kebebew
,
Fadlo R. Khuri
,
Jaegil Kim
,
Roger Kramer
,
Richard Kreisberg
,
Raju Kucherlapati
,
David J. Kwiatkowski
,
Marc Ladanyi
,
Phillip H Lai
,
Peter Laird
,
Eric S. Lander
,
Michael Lawrence
,
Darlene Lee
,
EunJung Lee
,
Semin Lee
,
William Lee
,
Kristen Leraas
,
Tara M Lichtenberg
,
Lee Lichtenstein
,
Lin Pei
,
Shiyun Ling
,
Jinze Liu
,
Wen Bin Liu
,
Yingchun Liu
,
Yiling Lu
,
Yussanne Ma
,
Harshad S Mahadeshwar
,
M. Marra
,
Michael Mayo
,
David G Mcfadden
,
Shaowu Meng
,
Matthew Meyerson
,
P. Mieczkowski
,
M L Miller
,
Gordon B. Mills
,
Richard A Moore
,
Lisle E. Mose
,
Andrew J. Mungall
,
Bradley A Murray
,
Marina N. Nikiforova
,
Michael S. Noble
,
Akinyemi I. Ojesina
,
Bradley A Ozenberger
,
Angeliki Pantazi
,
Michael Parfenov
,
Peter J. Park
,
Joel Wm. Parker
,
Evan O Paull
,
Chandra Sekhar Pedamallu
,
Jan F. Prins
,
Alexei Protopopov
,
Suresh S. Ramalingam
,
Nilsa C. Ramirez
,
Ricardo Ramírez
,
Benjamin J. Raphael
,
W. Kimryn Rathmell
,
Xiaojia Ren
,
Sheila M. Reynolds
,
Esther Rheinbay
,
Matthew D Ringel
,
Michael Rivera
,
Jeffrey Roach
,
A. Gordon Robertson
,
Mara Rosenberg
,
Matthew Rosenthal
,
Sara Sadeghi
,
Gordon Saksena
,
Chris Sander
,
Netty Santoso
,
Jacqueline E. Schein
,
N. Schultz
,
Steven Schumacher
,
Raja R. Seethala
,
J. G. Seidman
,
Yasin Şenbabaoğlu
,
Sahil Seth
,
Samantha Sharpe
,
Kenna R. Mills Shaw
,
John T. Shen
,
Ronglai Shen
,
Steven Sherman
,
Margi Sheth
,
Yan Shi
,
Ilya Shmulevich
,
Gabriel L. Sica
,
Janae V Simons
,
Rileen Sinha
,
Payal Sipahimalani
,
ROBERT C. SMALLRIDGE
,
Heidi J. Sofia
,
Matthew G Soloway
,
Xingzhi Song
,
Carrie Sougnez
,
Chip Stewart
,
Petar Stojanov
,
Joshua Urrutia
,
Onur Sumer
,
Yichao Sun
,
Barbara Tabak
,
Angela Tam
,
Donghui Tan
,
JIABIN TANG
,
Roy W. Tarnuzzer
,
Barry A. Taylor
,
Nina Thiessen
,
Leigh Thorne
,
Vesteinn Thorsson
,
R. Michael Tuttle
,
Christopher B. Umbricht
,
David Van Den Berg
,
Umadevi Veluvolu
,
Roel G.W. Verhaak
,
Michelle Vinco
,
Doug Voet
,
Vonn Walter
,
Zonghua Wang
,
Scot Waring
,
Paul M. Weinberger
,
Nils Weinhold
,
J. N. Weinstein
,
Daniel V. Weisenberger
,
David Wheeler
,
Matthew D. Wilkerson
,
Jocelyn Wilson
,
Michelle D. Williams
,
Daniel A. Winer
,
Lisa Wise
,
Junyuan Wu
,
Xi Liu
,
Andrew W Xu
,
Liming Yang
,
Lingfeng Yang
,
Travis I Zack
,
Martha A Zeiger
,
Dong Zeng
,
Jean C. Zenklusen
,
Ni Zhao
,
Hailei Zhang
,
Jianhua Zhang
,
Jiashan (julia) Zhang
,
Wei Zhang
,
Erik Zmuda
,
Lihua Zou
Publication type: Journal Article
Publication date: 2014-10-23
scimago Q1
wos Q1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
25417114
General Biochemistry, Genetics and Molecular Biology
Abstract
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of genomic variants, gene expression, and methylation demonstrated that different driver groups lead to different pathologies with distinct signaling and differentiation characteristics. Similarly, we identified distinct molecular subgroups of BRAF-mutant tumors, and multidimensional analyses highlighted a potential involvement of oncomiRs in less-differentiated subgroups. Our results propose a reclassification of thyroid cancers into molecular subtypes that better reflect their underlying signaling and differentiation properties, which has the potential to improve their pathological classification and better inform the management of the disease.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
20
40
60
80
100
120
|
|
|
Thyroid
116 publications, 4.76%
|
|
|
Cancers
81 publications, 3.32%
|
|
|
Journal of Clinical Endocrinology and Metabolism
72 publications, 2.95%
|
|
|
Frontiers in Endocrinology
65 publications, 2.67%
|
|
|
Endocrine Pathology
62 publications, 2.54%
|
|
|
International Journal of Molecular Sciences
42 publications, 1.72%
|
|
|
Endocrine-Related Cancer
41 publications, 1.68%
|
|
|
Endocrine
41 publications, 1.68%
|
|
|
Frontiers in Oncology
36 publications, 1.48%
|
|
|
Oncotarget
35 publications, 1.44%
|
|
|
Cancer cytopathology
35 publications, 1.44%
|
|
|
Scientific Reports
28 publications, 1.15%
|
|
|
Nature Communications
24 publications, 0.98%
|
|
|
PLoS ONE
23 publications, 0.94%
|
|
|
Clinical Cancer Research
20 publications, 0.82%
|
|
|
Surgery (US)
18 publications, 0.74%
|
|
|
Oncogene
17 publications, 0.7%
|
|
|
Modern Pathology
17 publications, 0.7%
|
|
|
Diagnostic Cytopathology
17 publications, 0.7%
|
|
|
Journal of Endocrinological Investigation
16 publications, 0.66%
|
|
|
Oncology Letters
14 publications, 0.57%
|
|
|
BMC Cancer
14 publications, 0.57%
|
|
|
Molecular and Cellular Endocrinology
14 publications, 0.57%
|
|
|
Histopathology
14 publications, 0.57%
|
|
|
Clinical Thyroidology
13 publications, 0.53%
|
|
|
Journal of Clinical Medicine
13 publications, 0.53%
|
|
|
Virchows Archiv
13 publications, 0.53%
|
|
|
Endocrinology
12 publications, 0.49%
|
|
|
Medicine (United States)
12 publications, 0.49%
|
|
|
20
40
60
80
100
120
|
Publishers
|
50
100
150
200
250
300
350
400
450
500
|
|
|
Springer Nature
490 publications, 20.11%
|
|
|
Elsevier
394 publications, 16.17%
|
|
|
Wiley
205 publications, 8.41%
|
|
|
MDPI
185 publications, 7.59%
|
|
|
Mary Ann Liebert
134 publications, 5.5%
|
|
|
Frontiers Media S.A.
131 publications, 5.38%
|
|
|
The Endocrine Society
100 publications, 4.1%
|
|
|
Cold Spring Harbor Laboratory
68 publications, 2.79%
|
|
|
Bioscientifica
56 publications, 2.3%
|
|
|
Taylor & Francis
54 publications, 2.22%
|
|
|
American Association for Cancer Research (AACR)
48 publications, 1.97%
|
|
|
Oxford University Press
47 publications, 1.93%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
44 publications, 1.81%
|
|
|
Impact Journals
41 publications, 1.68%
|
|
|
Spandidos Publications
38 publications, 1.56%
|
|
|
Public Library of Science (PLoS)
28 publications, 1.15%
|
|
|
SAGE
25 publications, 1.03%
|
|
|
Hindawi Limited
24 publications, 0.98%
|
|
|
American Medical Association (AMA)
19 publications, 0.78%
|
|
|
AME Publishing Company
19 publications, 0.78%
|
|
|
American Society of Clinical Oncology (ASCO)
17 publications, 0.7%
|
|
|
Georg Thieme Verlag KG
14 publications, 0.57%
|
|
|
S. Karger AG
13 publications, 0.53%
|
|
|
American Association of Clinical Endocrinology
10 publications, 0.41%
|
|
|
American Society for Clinical Investigation
8 publications, 0.33%
|
|
|
BMJ
8 publications, 0.33%
|
|
|
Korean Thyroid Association
8 publications, 0.33%
|
|
|
PeerJ
7 publications, 0.29%
|
|
|
American Association for the Advancement of Science (AAAS)
7 publications, 0.29%
|
|
|
50
100
150
200
250
300
350
400
450
500
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
2.4k
Total citations:
2438
Citations from 2024:
432
(17.73%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Agrawal N. et al. Integrated Genomic Characterization of Papillary Thyroid Carcinoma // Cell. 2014. Vol. 159. No. 3. pp. 676-690.
GOST all authors (up to 50)
Copy
Agrawal N. et al. Integrated Genomic Characterization of Papillary Thyroid Carcinoma // Cell. 2014. Vol. 159. No. 3. pp. 676-690.
Cite this
RIS
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Agrawal,
author = {Nishant Agrawal and Rehan Akbani and B Arman Aksoy and Adrian Ally and Harindra Arachchi and Sylvia L. Asa and James R. Auman and Miruna Balasundaram and Saianand Balu and STEPHEN B. BAYLIN and Madhusmita Behera and Brady Bernard and R. Beroukhim and Justin A. Bishop and Aaron D Black and Tom Bodenheimer and Lori Boice and Moiz S Bootwalla and Jay Bowen and Reanne Bowlby and Christopher A. Bristow and Robin Brookens and Denise Brooks and Robert Bryant and Elizabeth Buda and Yaron S N Butterfield and Tobias Carling and Rebecca Carlsen and Scott Carter and Sally E. Carty and Timothy A Chan and Amy Y Chen and Andrew D. Cherniack and Dorothy Cheung and Lynda Chin and Juok Cho and Andy Chu and Eric Chuah and Kristian Cibulskis and G. Ciriello and Amanda Clarke and Gary L. Clayman and Leslie Cope and John A Copland and Kyle Covington and Ludmila Danilova and Tanja Davidsen and John A Demchok and Daniel Dicara and Noreen Dhalla and others},
title = {Integrated Genomic Characterization of Papillary Thyroid Carcinoma},
journal = {Cell},
year = {2014},
volume = {159},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.cell.2014.09.050},
number = {3},
pages = {676--690},
doi = {10.1016/j.cell.2014.09.050}
}
Cite this
MLA
Copy
Agrawal, Nishant, et al. “Integrated Genomic Characterization of Papillary Thyroid Carcinoma.” Cell, vol. 159, no. 3, Oct. 2014, pp. 676-690. https://doi.org/10.1016/j.cell.2014.09.050.