Biological Functions of Autophagy Genes: A Disease Perspective
Тип публикации: Journal Article
Дата публикации: 2019-01-10
scimago Q1
wos Q1
БС1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
30633901
General Biochemistry, Genetics and Molecular Biology
Краткое описание
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory disorders and cancer. Autophagy selectively targets dysfunctional organelles, intracellular microbes, and pathogenic proteins, and deficiencies in these processes may lead to disease. Moreover, ATG genes have diverse physiologically important roles in other membrane-trafficking and signaling pathways. This Review discusses the biological functions of autophagy genes from the perspective of understanding-and potentially reversing-the pathophysiology of human disease and aging.
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ГОСТ |
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ГОСТ
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Levine B. et al. Biological Functions of Autophagy Genes: A Disease Perspective // Cell. 2019. Vol. 176. No. 1-2. pp. 11-42.
ГОСТ со всеми авторами (до 50)
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Levine B., Kroemer G. Biological Functions of Autophagy Genes: A Disease Perspective // Cell. 2019. Vol. 176. No. 1-2. pp. 11-42.
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RIS
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TY - JOUR
DO - 10.1016/j.cell.2018.09.048
UR - https://doi.org/10.1016/j.cell.2018.09.048
TI - Biological Functions of Autophagy Genes: A Disease Perspective
T2 - Cell
AU - Levine, Beth
AU - Kroemer, Guido
PY - 2019
DA - 2019/01/10
PB - Elsevier
SP - 11-42
IS - 1-2
VL - 176
PMID - 30633901
SN - 0092-8674
SN - 1097-4172
ER -
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BibTex (до 50 авторов)
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@article{2019_Levine,
author = {Beth Levine and Guido Kroemer},
title = {Biological Functions of Autophagy Genes: A Disease Perspective},
journal = {Cell},
year = {2019},
volume = {176},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.cell.2018.09.048},
number = {1-2},
pages = {11--42},
doi = {10.1016/j.cell.2018.09.048}
}
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MLA
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Levine, Beth, et al. “Biological Functions of Autophagy Genes: A Disease Perspective.” Cell, vol. 176, no. 1-2, Jan. 2019, pp. 11-42. https://doi.org/10.1016/j.cell.2018.09.048.