Cell

, volume 178 , issue 4 , pages 795-806.e12

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Erick Riquelme ^{1, 2}

Yu Zhang ³

Liang Zhang ⁴

Montiel Maria ³

Michelle Zoltan ³

Wenli Dong ⁵

Pompeyo R. Quesada ³

Ismet Sahin ⁶

Vidhi Chandra ³

Anthony San Lucas ⁷

Paul Scheet ⁷

Hanwen Xu ³

Samir Hanash ⁸

Lei Feng ⁵

Jared K. Burks ⁹

Kim-Anh Do ⁵

C Peterson ⁵

Deborah Nejman ¹⁰

Ching-Cherng Tzeng ^{11, 12, 13}

Michael P Kim ^{11, 12, 13}

Cynthia L. Sears ¹⁴

Nadim Ajami ¹⁵

Joseph F. Petrosino ¹⁵

Laura D. Wood ¹⁶

A. Maitra ¹⁷

Ravid Straussman ¹⁰

Matthew Katz ^{11, 12, 13}

James Robert White ¹⁸

Robert R. Jenq ⁴

Jennifer A. Wargo ¹⁹

Florencia McAllister ²⁰

Hide authors affiliations Show authors affiliations: 20 affiliations

Center for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile |

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |

Department of Clinical Cancer Prevention. The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |

⁴

Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA |

⁵

Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA |

⁶

Department of Engineering, Texas Southern University, Houston, TX, USA |

⁷

Department of Epidemiology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA |

⁸

McCombs Institute for the Early Detection and Treatment of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |

⁹

Department of leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |

¹⁰

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israël. |

¹¹

Department of Surgical Oncology

¹²

THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER |

¹³

Houston TX USA |

¹⁴

Departments of Medicine, Oncology and Molecular Microbiology & Immunology, Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, Baltimore, MD, USA |

¹⁵

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX USA |

¹⁶

Department of Pathology and The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA |

¹⁷

Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |

¹⁸

Resphera Biosciences, Baltimore, MD, USA |

¹⁹

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |

²⁰

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |

Publication type: Journal Article

Publication date: 2019-08-08

Elsevier

Cell

scimago Q1

wos Q1

SJR: 22.612

CiteScore: 74.8

Impact factor: 42.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2019.07.008

Copy DOI

PubMed ID: 31398337

General Biochemistry, Genetics and Molecular Biology

Abstract

Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S rRNA gene sequencing, we analyzed the tumor microbiome composition in PDAC patients with short-term survival (STS) and long-term survival (LTS). We found higher alpha-diversity in the tumor microbiome of LTS patients and identified an intra-tumoral microbiome signature (Pseudoxanthomonas-Streptomyces-Saccharopolyspora-Bacillus clausii) highly predictive of long-term survivorship in both discovery and validation cohorts. Through human-into-mice fecal microbiota transplantation (FMT) experiments from STS, LTS, or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. Our study demonstrates that PDAC microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.

Found

2 citations

Kataev Vladimir

15 publications, 108 citations, 2 reviews

h-index: 5

University of Tyumen

Institute for Cellular and Intracellular Symbiosis of the Ural Branch of the Russian Academy of Sciences

Research interests

Microbiology

NGS

1 citation

Cao Chengxi

177 publications, 2 834 citations, 11 reviews

h-index: 26

Shanghai Jiao Tong University

1 citation

Furuta Saori

40 publications, 1 169 citations, 125 reviews

h-index: 17

Case Western Reserve University

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Cite this

GOST |

Cite this

GOST Copy

Riquelme E. et al. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes // Cell. 2019. Vol. 178. No. 4. p. 795-806.e12.

GOST all authors (up to 50) Copy

Riquelme E., Zhang Yu., Zhang L., Maria M., Zoltan M., Dong W., Quesada P. R., Sahin I., Chandra V., San Lucas A., Scheet P., Xu H., Hanash S., Feng L., Burks J. K., Do K., Peterson C., Nejman D., Tzeng C., Kim M. P., Sears C. L., Ajami N., Petrosino J. F., Wood L. D., Maitra A., Straussman R., Katz M., White J. R., Jenq R. R., Wargo J. A., McAllister F. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes // Cell. 2019. Vol. 178. No. 4. p. 795-806.e12.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2019.07.008

UR - https://doi.org/10.1016/j.cell.2019.07.008

TI - Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

T2 - Cell

AU - Riquelme, Erick

AU - Zhang, Yu

AU - Zhang, Liang

AU - Maria, Montiel

AU - Zoltan, Michelle

AU - Dong, Wenli

AU - Quesada, Pompeyo R.

AU - Sahin, Ismet

AU - Chandra, Vidhi

AU - San Lucas, Anthony

AU - Scheet, Paul

AU - Xu, Hanwen

AU - Hanash, Samir

AU - Feng, Lei

AU - Burks, Jared K.

AU - Do, Kim-Anh

AU - Peterson, C

AU - Nejman, Deborah

AU - Tzeng, Ching-Cherng

AU - Kim, Michael P

AU - Sears, Cynthia L.

AU - Ajami, Nadim

AU - Petrosino, Joseph F.

AU - Wood, Laura D.

AU - Maitra, A.

AU - Straussman, Ravid

AU - Katz, Matthew

AU - White, James Robert

AU - Jenq, Robert R.

AU - Wargo, Jennifer A.

AU - McAllister, Florencia

PY - 2019

DA - 2019/08/08

PB - Elsevier

SP - 795-806.e12

IS - 4

VL - 178

PMID - 31398337

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Riquelme,

author = {Erick Riquelme and Yu Zhang and Liang Zhang and Montiel Maria and Michelle Zoltan and Wenli Dong and Pompeyo R. Quesada and Ismet Sahin and Vidhi Chandra and Anthony San Lucas and Paul Scheet and Hanwen Xu and Samir Hanash and Lei Feng and Jared K. Burks and Kim-Anh Do and C Peterson and Deborah Nejman and Ching-Cherng Tzeng and Michael P Kim and Cynthia L. Sears and Nadim Ajami and Joseph F. Petrosino and Laura D. Wood and A. Maitra and Ravid Straussman and Matthew Katz and James Robert White and Robert R. Jenq and Jennifer A. Wargo and Florencia McAllister},

title = {Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes},

journal = {Cell},

year = {2019},

volume = {178},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/j.cell.2019.07.008},

number = {4},

pages = {795--806.e12},

doi = {10.1016/j.cell.2019.07.008}

}

MLA

Cite this

MLA Copy

Riquelme, Erick, et al. “Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.” Cell, vol. 178, no. 4, Aug. 2019, pp. 795-806.e12. https://doi.org/10.1016/j.cell.2019.07.008.

Publisher

Elsevier

Journal

Cell

scimago Q1

wos Q1

SJR

22.612

CiteScore

74.8

Impact factor

42.5

ISSN

00928674 (Print)

10974172 (Electronic)