Hallmarks of Health
Publication type: Journal Article
Publication date: 2021-01-01
scimago Q1
wos Q1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
33340459
General Biochemistry, Genetics and Molecular Biology
Abstract
Summary
Health is usually defined as the absence of pathology. Here, we endeavor to define health as a compendium of organizational and dynamic features that maintain physiology. The biological causes or hallmarks of health include features of spatial compartmentalization (integrity of barriers and containment of local perturbations), maintenance of homeostasis over time (recycling and turnover, integration of circuitries, and rhythmic oscillations), and an array of adequate responses to stress (homeostatic resilience, hormetic regulation, and repair and regeneration). Disruption of any of these interlocked features is broadly pathogenic, causing an acute or progressive derailment of the system coupled to the loss of numerous stigmata of health.Found
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Metrics
374
Total citations:
374
Citations from 2024:
160
(42.78%)
Cite this
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MLA
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.cell.2020.11.034
UR - https://doi.org/10.1016/j.cell.2020.11.034
TI - Hallmarks of Health
T2 - Cell
AU - López-Otín, C.
AU - Kroemer, Guido
PY - 2021
DA - 2021/01/01
PB - Elsevier
SP - 33-63
IS - 1
VL - 184
PMID - 33340459
SN - 0092-8674
SN - 1097-4172
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_López-Otín,
author = {C. López-Otín and Guido Kroemer},
title = {Hallmarks of Health},
journal = {Cell},
year = {2021},
volume = {184},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.cell.2020.11.034},
number = {1},
pages = {33--63},
doi = {10.1016/j.cell.2020.11.034}
}
Cite this
MLA
Copy
López-Otín, C., et al. “Hallmarks of Health.” Cell, vol. 184, no. 1, Jan. 2021, pp. 33-63. https://doi.org/10.1016/j.cell.2020.11.034.