Cell, volume 186, issue 17, pages 3548-3557

An ethical framework for human embryology with embryo models

Nicolas Rivron ¹

Alfonso Arias ²

Martin F. Pera ³

Naomi Moris ⁴

Hafez Ismaili Mhamdi ⁵

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), 1030 Vienna, Austria |

Systems Bioengineering, DCEXS, Universidad Pompeu Fabra, Doctor Aiguader 88 ICREA (Institució Catalana de Recerca i Estudis Avançats), Barcelona, Spain

The Jackson Laboratory, Bar Harbor, ME, USA |

⁴

The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK |

⁵

Department of Medical Ethics, Philosophy and History of Medicine, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands |

Publication type: Journal Article

Publication date: 2023-08-17

Elsevier

Journal: Cell

scimago Q1

SJR: 24.342

CiteScore: 110.0

Impact factor: 45.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2023.07.028

Copy DOI

General Biochemistry, Genetics and Molecular Biology

Abstract

A human embryo’s legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest “tipping points” for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.

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Publisher

Elsevier

Journal

Cell

scimago Q1

SJR

24.342

CiteScore

110.0

Impact factor

45.5

ISSN

00928674 (Print)

10974172 (Electronic)

An ethical framework for human embryology with embryo models

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