Cell

, volume 186 , issue 18 , pages 3758-3775

Biomarkers of aging for the identification and evaluation of longevity interventions

Mahdi Moqri ^{1, 2, 3}

Chiara Herzog ⁴

Jesse R Poganik ³

Jamie N. Justice ⁵

Daniel W. Belsky ⁶

Albert T. Higgins-Chen ⁷

А. А. Москалев ⁸

Georg Fuellen ^{9, 10}

Alan A. Cohen ¹¹

Ivan Bautmans ^{12, 13}

Martin Widschwendter ^{4, 14, 15}

Junfei Ding ¹⁶

G. Alexander Fleming ¹⁷

Joan Mannick ¹⁸

Jing-Dong J. Han ¹⁹

Alex Zhavoronkov ²⁰

N. Barzilai ²¹

Matt Kaeberlein ²²

Steven Cummings ^{23, 24}

Brian K Kennedy ²⁵

Luigi Ferrucci ²⁶

Steve Horvath ²⁷

Eric Verdin ²⁸

Andrea Daniela Maier ^{29, 30}

Michael P. Snyder ¹

Vittorio Sebastiano ²

Vadim N. Gladyshev ³

Hide authors affiliations Show authors affiliations: 30 affiliations

Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA |

Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA |

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Harvard University

Brigham and Women's Hospital

⁴

European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria |

⁵

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA |

⁶

Department of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA |

⁷

Department of Psychiatry, Yale University, New Haven, CT, USA |

⁸

Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia |

⁹

Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany |

¹⁰

School Of Medicine, University College Dublin, Dublin, Ireland |

¹¹

Department of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA |

¹²

Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium |

¹³

Gerontology Department, Vrije Universiteit Brussel, Brussels, Belgium |

¹⁴

Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, UK |

¹⁵

Department of Women’s and Children’s Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden |

¹⁶

Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA |

¹⁷

Kitalys Institute, Charlottesville, VA, USA |

¹⁸

Tornado Therapeutics, New York, NY, USA |

¹⁹

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China |

²⁰

Insilico Medicine Hong Kong, Pak Shek Kok, New Territories, Hong Kong SAR, China |

²¹

Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA |

²²

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA |

²³

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA |

²⁴

San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA |

²⁵

Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore |

²⁶

National Institute on Aging, Baltimore, MD, USA |

²⁷

Altos Labs, San Diego, CA, USA |

²⁸

Buck Institute for Research on Aging, Novato, CA, USA |

²⁹

Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands |

³⁰

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore |

Publication type: Journal Article

Publication date: 2023-08-31

Elsevier

Cell

scimago Q1

wos Q1

SJR: 22.612

CiteScore: 74.8

Impact factor: 42.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2023.08.003

Copy DOI

PubMed ID: 37657418

General Biochemistry, Genetics and Molecular Biology

Abstract

With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

Found

5 citations

Moskalev Alexey

205 publications, 7 262 citations, 16 reviews

h-index: 42

Petrovsky National Research Centre of Surgery

2 citations

LEMAITRE Jean-Marc

79 publications, 2 962 citations

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1 citation

Golubev Denis

🤝

19 publications, 125 citations

h-index: 6

Institute of Biology Komi SC of the Ural Branch of the Russian Academy of Sciences

Pitirim Sorokin Syktyvkar State University

1 citation

Sidorenko Denis

3 publications, 21 citations

h-index: 2

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Cite this

GOST |

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GOST Copy

Moqri M. et al. Biomarkers of aging for the identification and evaluation of longevity interventions // Cell. 2023. Vol. 186. No. 18. pp. 3758-3775.

GOST all authors (up to 50) Copy

Moqri M., Herzog C., Poganik J. R., Justice J. N., Belsky D. W., Higgins-Chen A. T., Москалев А. А., Fuellen G., Cohen A. A., Bautmans I., Widschwendter M., Ding J., Alexander Fleming G., Mannick J., Han J. J., Zhavoronkov A., Barzilai N., Kaeberlein M., Cummings S., Kennedy B. K., Ferrucci L., Horvath S., Verdin E., Daniela Maier A., Snyder M. P., Sebastiano V., Gladyshev V. N. Biomarkers of aging for the identification and evaluation of longevity interventions // Cell. 2023. Vol. 186. No. 18. pp. 3758-3775.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2023.08.003

UR - https://doi.org/10.1016/j.cell.2023.08.003

TI - Biomarkers of aging for the identification and evaluation of longevity interventions

T2 - Cell

AU - Moqri, Mahdi

AU - Herzog, Chiara

AU - Poganik, Jesse R

AU - Justice, Jamie N.

AU - Belsky, Daniel W.

AU - Higgins-Chen, Albert T.

AU - Москалев, А. А.

AU - Fuellen, Georg

AU - Cohen, Alan A.

AU - Bautmans, Ivan

AU - Widschwendter, Martin

AU - Ding, Junfei

AU - Alexander Fleming, G.

AU - Mannick, Joan

AU - Han, Jing-Dong J.

AU - Zhavoronkov, Alex

AU - Barzilai, N.

AU - Kaeberlein, Matt

AU - Cummings, Steven

AU - Kennedy, Brian K

AU - Ferrucci, Luigi

AU - Horvath, Steve

AU - Verdin, Eric

AU - Daniela Maier, Andrea

AU - Snyder, Michael P.

AU - Sebastiano, Vittorio

AU - Gladyshev, Vadim N.

PY - 2023

DA - 2023/08/31

PB - Elsevier

SP - 3758-3775

IS - 18

VL - 186

PMID - 37657418

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Moqri,

author = {Mahdi Moqri and Chiara Herzog and Jesse R Poganik and Jamie N. Justice and Daniel W. Belsky and Albert T. Higgins-Chen and А. А. Москалев and Georg Fuellen and Alan A. Cohen and Ivan Bautmans and Martin Widschwendter and Junfei Ding and G. Alexander Fleming and Joan Mannick and Jing-Dong J. Han and Alex Zhavoronkov and N. Barzilai and Matt Kaeberlein and Steven Cummings and Brian K Kennedy and Luigi Ferrucci and Steve Horvath and Eric Verdin and Andrea Daniela Maier and Michael P. Snyder and Vittorio Sebastiano and Vadim N. Gladyshev},

title = {Biomarkers of aging for the identification and evaluation of longevity interventions},

journal = {Cell},

year = {2023},

volume = {186},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/j.cell.2023.08.003},

number = {18},

pages = {3758--3775},

doi = {10.1016/j.cell.2023.08.003}

}

MLA

Cite this

MLA Copy

Moqri, Mahdi, et al. “Biomarkers of aging for the identification and evaluation of longevity interventions.” Cell, vol. 186, no. 18, Aug. 2023, pp. 3758-3775. https://doi.org/10.1016/j.cell.2023.08.003.

Publisher

Elsevier

Journal

Cell

scimago Q1

wos Q1

SJR

22.612

CiteScore

74.8

Impact factor

42.5

ISSN

00928674 (Print)

10974172 (Electronic)

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