In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histological, and molecular evaluations, substantiating metformin's influence on delaying age-related phenotypes at the organismal level. Specifically, we leveraged pan-tissue transcriptomics, DNA methylomics, plasma proteomics, and metabolomics to develop innovative monkey aging clocks and applied these to gauge metformin's effects on aging. The results highlighted a significant slowing of aging indicators, notably a roughly 6-year regression in brain aging. Metformin exerts a substantial neuroprotective effect, preserving brain structure and enhancing cognitive ability. The geroprotective effects on primate neurons were partially mediated by the activation of Nrf2, a transcription factor with anti-oxidative capabilities. Our research pioneers the systemic reduction of multi-dimensional biological age in primates through metformin, paving the way for advancing pharmaceutical strategies against human aging.

Found

1 citation

Zhang Ting

3 publications, 18 citations, 7 reviews

h-index: 1

University of Pittsburgh

Top-30

Journals

	1 2 3 4 5
Cell	Cell, 5, 4.35% Cell 5 publications, 4.35%
Nature Aging	Nature Aging, 5, 4.35% Nature Aging 5 publications, 4.35%
Ageing Research Reviews	Ageing Research Reviews, 4, 3.48% Ageing Research Reviews 4 publications, 3.48%
Scientific Reports	Scientific Reports, 4, 3.48% Scientific Reports 4 publications, 3.48%
Life Medicine	Life Medicine, 3, 2.61% Life Medicine 3 publications, 2.61%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 2, 1.74% Signal Transduction and Targeted Therapy 2 publications, 1.74%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 1.74% International Journal of Molecular Sciences 2 publications, 1.74%
Translational Neurodegeneration	Translational Neurodegeneration, 2, 1.74% Translational Neurodegeneration 2 publications, 1.74%
Cells	Cells, 2, 1.74% Cells 2 publications, 1.74%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 2, 1.74% Proceedings of the National Academy of Sciences of the United States of America 2 publications, 1.74%
Pharmaceuticals	Pharmaceuticals, 2, 1.74% Pharmaceuticals 2 publications, 1.74%
Molecular Neurobiology	Molecular Neurobiology, 2, 1.74% Molecular Neurobiology 2 publications, 1.74%
FASEB Journal	FASEB Journal, 2, 1.74% FASEB Journal 2 publications, 1.74%
Aging Cell	Aging Cell, 2, 1.74% Aging Cell 2 publications, 1.74%
JAMA - Journal of the American Medical Association	JAMA - Journal of the American Medical Association, 2, 1.74% JAMA - Journal of the American Medical Association 2 publications, 1.74%
MedComm	MedComm, 2, 1.74% MedComm 2 publications, 1.74%
Nature	Nature, 1, 0.87% Nature 1 publication, 0.87%
Trends in Genetics	Trends in Genetics, 1, 0.87% Trends in Genetics 1 publication, 0.87%
Advanced healthcare materials	Advanced healthcare materials, 1, 0.87% Advanced healthcare materials 1 publication, 0.87%
Lab Animal	Lab Animal, 1, 0.87% Lab Animal 1 publication, 0.87%
Cell Metabolism	Cell Metabolism, 1, 0.87% Cell Metabolism 1 publication, 0.87%
npj Metabolic Health and Disease	npj Metabolic Health and Disease, 1, 0.87% npj Metabolic Health and Disease 1 publication, 0.87%
Neuron	Neuron, 1, 0.87% Neuron 1 publication, 0.87%
The Journal of Cardiovascular Aging	The Journal of Cardiovascular Aging, 1, 0.87% The Journal of Cardiovascular Aging 1 publication, 0.87%
Current Opinion in Genetics and Development	Current Opinion in Genetics and Development, 1, 0.87% Current Opinion in Genetics and Development 1 publication, 0.87%
Transplantation	Transplantation, 1, 0.87% Transplantation 1 publication, 0.87%
STAR Protocols	STAR Protocols, 1, 0.87% STAR Protocols 1 publication, 0.87%
Molecules	Molecules, 1, 0.87% Molecules 1 publication, 0.87%
Nature Reviews Cardiology	Nature Reviews Cardiology, 1, 0.87% Nature Reviews Cardiology 1 publication, 0.87%
	1 2 3 4 5

Publishers

	5 10 15 20 25 30 35
Springer Nature	Springer Nature, 35, 30.43% Springer Nature 35 publications, 30.43%
Elsevier	Elsevier, 29, 25.22% Elsevier 29 publications, 25.22%
Wiley	Wiley, 10, 8.7% Wiley 10 publications, 8.7%
MDPI	MDPI, 8, 6.96% MDPI 8 publications, 6.96%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 7, 6.09% Cold Spring Harbor Laboratory 7 publications, 6.09%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 4, 3.48% Ovid Technologies (Wolters Kluwer Health) 4 publications, 3.48%
Oxford University Press	Oxford University Press, 4, 3.48% Oxford University Press 4 publications, 3.48%
Frontiers Media S.A.	Frontiers Media S.A., 3, 2.61% Frontiers Media S.A. 3 publications, 2.61%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 1.74% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 1.74%
American Medical Association (AMA)	American Medical Association (AMA), 2, 1.74% American Medical Association (AMA) 2 publications, 1.74%
OAE Publishing Inc.	OAE Publishing Inc., 1, 0.87% OAE Publishing Inc. 1 publication, 0.87%
Tsinghua University Press	Tsinghua University Press, 1, 0.87% Tsinghua University Press 1 publication, 0.87%
Hans Publishers	Hans Publishers, 1, 0.87% Hans Publishers 1 publication, 0.87%
Annual Reviews	Annual Reviews, 1, 0.87% Annual Reviews 1 publication, 0.87%
Walter de Gruyter	Walter de Gruyter, 1, 0.87% Walter de Gruyter 1 publication, 0.87%
Science in China Press	Science in China Press, 1, 0.87% Science in China Press 1 publication, 0.87%
International Dose-Response Society	International Dose-Response Society, 1, 0.87% International Dose-Response Society 1 publication, 0.87%
American Physiological Society	American Physiological Society, 1, 0.87% American Physiological Society 1 publication, 0.87%
EDP Sciences	EDP Sciences, 1, 0.87% EDP Sciences 1 publication, 0.87%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 0.87% American Chemical Society (ACS) 1 publication, 0.87%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.87% American Association for the Advancement of Science (AAAS) 1 publication, 0.87%
	5 10 15 20 25 30 35

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Metrics

115

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GOST |

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GOST Copy

Yang Y. et al. Metformin decelerates aging clock in male monkeys // Cell. 2024. Vol. 187. No. 22. p. 6358-6378.e29.

GOST all authors (up to 50) Copy

Yang Y. et al. Metformin decelerates aging clock in male monkeys // Cell. 2024. Vol. 187. No. 22. p. 6358-6378.e29.

RIS |

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RIS

BibTex |

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BibTex (up to 50 authors) Copy

@article{2024_Yang,

author = {Yuan-Han Yang and Xiaoyong Lu and Ning Liu and Shuai Ma and Hui Zhang and Zhiyi Zhang and Kuan Yang and Mengmeng Jiang and Zikai Zheng and Yicheng Qiao and Qin-Chao Hu and Ying Huang and Yi-Long Wu and Yiyuan Zhang and Muzhao Xiong and Lixiao Liu and Xiao-Yu Jiang and Pradeep Reddy and Xueda Dong and Xiao-Bo Dong and Fanshu Xu and Qiaoran Wang and Qian Zhao and Jinghui Lei and Shuhui Sun and Ying Jing and Jingyi Li and Yusheng Cai and Yanling Fan and Kao-Wen Yan and Yaobin Jing and Amin Haghani and Mengen Xing and Xuan Zhang and Guo Dong Zhu and Weihong Song and Steve Horvath and Concepcion Rodriguez Esteban and Moshi Song and Si Wang and Guo-guang ZHAO and Wei Liu and Wei Li and Juan A. Belmonte and Jing Qu and Wei-Qi Zhang and Guanghui Liu and others},

title = {Metformin decelerates aging clock in male monkeys},

journal = {Cell},

year = {2024},

volume = {187},

publisher = {Elsevier},

month = {oct},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0092867424009140},

number = {22},

pages = {6358--6378.e29},

doi = {10.1016/j.cell.2024.08.021}

}

MLA

Cite this

MLA Copy

Yang, Yuanhan, et al. “Metformin decelerates aging clock in male monkeys.” Cell, vol. 187, no. 22, Oct. 2024, pp. 6358-6378.e29. https://linkinghub.elsevier.com/retrieve/pii/S0092867424009140.

Publisher

Elsevier

Journal

Cell

scimago Q1

wos Q1

SJR

22.612

CiteScore

74.8

Impact factor

42.5

ISSN

00928674 (Print)

10974172 (Electronic)

Profiles

Ying Ying Jing