Open Access
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
Olga Bielska
1
,
Lucile Guerber
1
,
Stéphane Schmucker
1
,
Arantxa Agote Arán
1
,
Taozhi Ye
1
,
Yongrong Liao
1
,
Marta Puig Gamez
1
,
Erwan Grandgirard
1
,
Charlotte Kleiss
1
,
Yansheng Liu
2
,
Emmanuel Compe
1
,
Zhirong Zhang
1
,
Ruedi Aebersold
3, 4
,
Romeo Ricci
1
,
Izabela Sumara
1
1
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
|
Publication type: Journal Article
Publication date: 2021-05-18
scimago Q1
wos Q1
SJR: 3.796
CiteScore: 12.9
Impact factor: 6.9
ISSN: 22111247, 26391856
PubMed ID:
34010649
General Biochemistry, Genetics and Molecular Biology
Abstract
Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression remains largely unknown. Here, we discover a pathway linking mitochondrial fission to mitotic progression in mammalian cells. The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells. Phosphorylation of MFF is crucial for chromosome segregation and promotes cell survival by inhibiting adaptation of the mitotic checkpoint. Thus, PKD/MFF-dependent mitochondrial fission is critical for the maintenance of genome integrity during cell division.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
EMBO Reports
2 publications, 7.14%
|
|
|
Journal of Cell Science
2 publications, 7.14%
|
|
|
International Journal of Molecular Sciences
1 publication, 3.57%
|
|
|
Frontiers in Cell and Developmental Biology
1 publication, 3.57%
|
|
|
Nature Reviews Cardiology
1 publication, 3.57%
|
|
|
Cardiovascular Diabetology
1 publication, 3.57%
|
|
|
Journal of Cell Biology
1 publication, 3.57%
|
|
|
Biomolecules
1 publication, 3.57%
|
|
|
Diagnostics
1 publication, 3.57%
|
|
|
Cell Cycle
1 publication, 3.57%
|
|
|
Current Opinion in Cell Biology
1 publication, 3.57%
|
|
|
Biochimica et Biophysica Acta - Molecular Cell Research
1 publication, 3.57%
|
|
|
Frontiers in Molecular Biosciences
1 publication, 3.57%
|
|
|
Biochemical Society Transactions
1 publication, 3.57%
|
|
|
Science
1 publication, 3.57%
|
|
|
Trends in Endocrinology and Metabolism
1 publication, 3.57%
|
|
|
Pharmacological Research
1 publication, 3.57%
|
|
|
Science advances
1 publication, 3.57%
|
|
|
Nature Cell Biology
1 publication, 3.57%
|
|
|
iScience
1 publication, 3.57%
|
|
|
Nature Communications
1 publication, 3.57%
|
|
|
Biochemistry
1 publication, 3.57%
|
|
|
Cell Biochemistry and Biophysics
1 publication, 3.57%
|
|
|
Annual Review of Cell and Developmental Biology
1 publication, 3.57%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
6
|
|
|
Springer Nature
6 publications, 21.43%
|
|
|
Elsevier
5 publications, 17.86%
|
|
|
MDPI
3 publications, 10.71%
|
|
|
Frontiers Media S.A.
2 publications, 7.14%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 7.14%
|
|
|
American Association for the Advancement of Science (AAAS)
2 publications, 7.14%
|
|
|
The Company of Biologists
2 publications, 7.14%
|
|
|
Rockefeller University Press
1 publication, 3.57%
|
|
|
European Molecular Biology Organization
1 publication, 3.57%
|
|
|
Taylor & Francis
1 publication, 3.57%
|
|
|
Portland Press
1 publication, 3.57%
|
|
|
American Chemical Society (ACS)
1 publication, 3.57%
|
|
|
Annual Reviews
1 publication, 3.57%
|
|
|
1
2
3
4
5
6
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
28
Total citations:
28
Citations from 2024:
17
(60.71%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Pangou E. et al. A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression // Cell Reports. 2021. Vol. 35. No. 7. p. 109129.
GOST all authors (up to 50)
Copy
Bielska O., Guerber L., Schmucker S., Agote Arán A., Ye T., Liao Y., Puig Gamez M., Grandgirard E., Kleiss C., Liu Y., Compe E., Zhang Z., Aebersold R., Ricci R., Sumara I. A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression // Cell Reports. 2021. Vol. 35. No. 7. p. 109129.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.celrep.2021.109129
UR - https://doi.org/10.1016/j.celrep.2021.109129
TI - A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
T2 - Cell Reports
AU - Bielska, Olga
AU - Guerber, Lucile
AU - Schmucker, Stéphane
AU - Agote Arán, Arantxa
AU - Ye, Taozhi
AU - Liao, Yongrong
AU - Puig Gamez, Marta
AU - Grandgirard, Erwan
AU - Kleiss, Charlotte
AU - Liu, Yansheng
AU - Compe, Emmanuel
AU - Zhang, Zhirong
AU - Aebersold, Ruedi
AU - Ricci, Romeo
AU - Sumara, Izabela
PY - 2021
DA - 2021/05/18
PB - Elsevier
SP - 109129
IS - 7
VL - 35
PMID - 34010649
SN - 2211-1247
SN - 2639-1856
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Pangou,
author = {Olga Bielska and Lucile Guerber and Stéphane Schmucker and Arantxa Agote Arán and Taozhi Ye and Yongrong Liao and Marta Puig Gamez and Erwan Grandgirard and Charlotte Kleiss and Yansheng Liu and Emmanuel Compe and Zhirong Zhang and Ruedi Aebersold and Romeo Ricci and Izabela Sumara},
title = {A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression},
journal = {Cell Reports},
year = {2021},
volume = {35},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.celrep.2021.109129},
number = {7},
pages = {109129},
doi = {10.1016/j.celrep.2021.109129}
}
Cite this
MLA
Copy
Pangou, Evanthia, et al. “A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression.” Cell Reports, vol. 35, no. 7, May. 2021, p. 109129. https://doi.org/10.1016/j.celrep.2021.109129.