Open Access
Open access
Elsevier
Cell Reports
,  volume 42 ,  issue 9 ,  pages 113131

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

Mueez U Din 1, 2
, 
Vanessa Derenji De Mello 3
, 
Marjo Tuomainen 3
, 
Juho Raiko 1
, 
Tarja Niemi 4
, 
Tobias Fromme 5, 6, 7
, 
Anton Klåvus 3
, 
Nadine GAUTIER 8
, 
Kimmo Haimilahti 9, 10
, 
Marko Lehtonen 11
, 
K Kristiansen 12
, 
John Newman 13, 14, 15
, 
KIRSI H. PIETILÄINEN 16, 17
, 
Jussi Pihlajamäki 3, 18
, 
Ez-Zoubir AMRI 8
, 
Martin Klingenspor 5, 6, 7
, 
Pirjo Nuutila 1, 2, 19
, 
Eija Pirinen 9, 20
, 
K. Hanhineva 3, 21, 22
, 
Kirsi A. Virtanen 1, 2, 3, 18, 19
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Publication type: Journal Article
Publication date: 2023-09-13
Elsevier
scimago Q1
wos Q1
SJR: 3.796
CiteScore: 12.9
Impact factor: 6.9
ISSN: 22111247, 26391856
General Biochemistry, Genetics and Molecular Biology
Abstract
Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
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GOST |
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GOST Copy
U Din M. et al. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans // Cell Reports. 2023. Vol. 42. No. 9. p. 113131.
GOST all authors (up to 50) Copy
U Din M., De Mello V. D., Tuomainen M., Raiko J., Niemi T., Fromme T., Klåvus A., GAUTIER N., Haimilahti K., Lehtonen M., Kristiansen K., Newman J., PIETILÄINEN K. H., Pihlajamäki J., AMRI E., Klingenspor M., Nuutila P., Pirinen E., Hanhineva K., Virtanen K. A. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans // Cell Reports. 2023. Vol. 42. No. 9. p. 113131.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.celrep.2023.113131
UR - https://doi.org/10.1016/j.celrep.2023.113131
TI - Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
T2 - Cell Reports
AU - U Din, Mueez
AU - De Mello, Vanessa Derenji
AU - Tuomainen, Marjo
AU - Raiko, Juho
AU - Niemi, Tarja
AU - Fromme, Tobias
AU - Klåvus, Anton
AU - GAUTIER, Nadine
AU - Haimilahti, Kimmo
AU - Lehtonen, Marko
AU - Kristiansen, K
AU - Newman, John
AU - PIETILÄINEN, KIRSI H.
AU - Pihlajamäki, Jussi
AU - AMRI, Ez-Zoubir
AU - Klingenspor, Martin
AU - Nuutila, Pirjo
AU - Pirinen, Eija
AU - Hanhineva, K.
AU - Virtanen, Kirsi A.
PY - 2023
DA - 2023/09/13
PB - Elsevier
SP - 113131
IS - 9
VL - 42
PMID - 37708023
SN - 2211-1247
SN - 2639-1856
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_U Din,
author = {Mueez U Din and Vanessa Derenji De Mello and Marjo Tuomainen and Juho Raiko and Tarja Niemi and Tobias Fromme and Anton Klåvus and Nadine GAUTIER and Kimmo Haimilahti and Marko Lehtonen and K Kristiansen and John Newman and KIRSI H. PIETILÄINEN and Jussi Pihlajamäki and Ez-Zoubir AMRI and Martin Klingenspor and Pirjo Nuutila and Eija Pirinen and K. Hanhineva and Kirsi A. Virtanen},
title = {Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans},
journal = {Cell Reports},
year = {2023},
volume = {42},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.celrep.2023.113131},
number = {9},
pages = {113131},
doi = {10.1016/j.celrep.2023.113131}
}
MLA
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MLA Copy
U. Din, Mueez, et al. “Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans.” Cell Reports, vol. 42, no. 9, Sep. 2023, p. 113131. https://doi.org/10.1016/j.celrep.2023.113131.