Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study
Hosim Soh
1
,
Hyun Jung Lee
1
,
Kyungdo Han
2
,
Seona Park
1
,
Seung Min Hong
1
,
Jung Min Moon
1
,
E Y Kang
1
,
Jooyoung Lee
3, 4
,
J.-H. Chun
5, 6, 7
,
Jong Chan Im
1
,
Joo Young Kim
1
7
Seoul Republic of Korea
|
Publication type: Journal Article
Publication date: 2021-10-01
scimago Q1
wos Q1
SJR: 3.509
CiteScore: 18.2
Impact factor: 12.0
ISSN: 15423565, 15427714
PubMed ID:
32712393
Gastroenterology
Hepatology
Abstract
Background & Aims
The association between atopic diseases and inflammatory bowel diseases (IBD) is unclear. We conducted a nationwide population-based study in Korea to investigate the effect of atopic diseases on the development of IBD.Methods
A total of 9,923,521 participants, who received a medical check-up in 2009, were included and followed through 2017. The presence of any atopic diseases, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma, was evaluated. Patients who developed IBD, including Crohn's disease (CD) and ulcerative colitis (UC), were identified using claims data from National Health Insurance; the association between atopic diseases and the risk of IBD was evaluated using Cox proportional hazard models, and presented as adjusted hazard ratios (aHRs) with 95% CIs.Results
During a mean follow-up period of 7.3 years, 1419 patients (0.014%) developed CD and 5897 patients (0.059%) developed UC. The incidences of CD (per 100,000 person-years) were 3.756, 2.248, and 2.346 in patients with AD, AR, or asthma, respectively. The incidences of UC were 11.952, 9.818, and 9.358 in patients with AD, AR, or asthma, respectively. Multivariable analysis revealed that the aHRs for incident CD in patients with AD, AR, or asthma were 2.02, 1.33, and 1.60 (95% CIs, 1.118–3.663, 1.149–1.529, and 1.193–2.136, respectively) compared with controls. The risks of incident UC in patients with AD, AR, or asthma were 1.51, 1.32, and 1.29 (95% CIs, 1.082–2.104, 1.229–1.410, and 1.115–1.491, respectively) compared with controls. Moreover, an increase in the number of atopic diseases gradually increased the risk for CD and UC; for 1 or 2 or more atopic diseases, the aHRs for CD were 1.35 and 1.65 (95% CIs, 1.171–1.560 and 1.146–2.376), and the aHRs for UC were 1.30 and 1.49 (95% CIs, 1.211–1.392 and 1.249–1.774), respectively.Conclusions
Based on a nationwide population-based study in Korea, patients with any atopic disease, including AD, AR, or asthma, have an increased risk for CD and UC. The risk for IBD increases with the increase in the number of atopic diseases.Found
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GOST
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Soh H. et al. Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study // Clinical Gastroenterology and Hepatology. 2021. Vol. 19. No. 10. pp. 2072-2081000000.
GOST all authors (up to 50)
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Soh H., Lee H. J., Han K., Park S., Hong S. M., Moon J. M., Kang E. Y., Lee J., Chun J., Im J. C., Kim J. Y. Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study // Clinical Gastroenterology and Hepatology. 2021. Vol. 19. No. 10. pp. 2072-2081000000.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.cgh.2020.07.049
UR - https://doi.org/10.1016/j.cgh.2020.07.049
TI - Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study
T2 - Clinical Gastroenterology and Hepatology
AU - Soh, Hosim
AU - Lee, Hyun Jung
AU - Han, Kyungdo
AU - Park, Seona
AU - Hong, Seung Min
AU - Moon, Jung Min
AU - Kang, E Y
AU - Lee, Jooyoung
AU - Chun, J.-H.
AU - Im, Jong Chan
AU - Kim, Joo Young
PY - 2021
DA - 2021/10/01
PB - Elsevier
SP - 2072-2081000000
IS - 10
VL - 19
PMID - 32712393
SN - 1542-3565
SN - 1542-7714
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Soh,
author = {Hosim Soh and Hyun Jung Lee and Kyungdo Han and Seona Park and Seung Min Hong and Jung Min Moon and E Y Kang and Jooyoung Lee and J.-H. Chun and Jong Chan Im and Joo Young Kim},
title = {Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study},
journal = {Clinical Gastroenterology and Hepatology},
year = {2021},
volume = {19},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.cgh.2020.07.049},
number = {10},
pages = {2072--2081000000},
doi = {10.1016/j.cgh.2020.07.049}
}
Cite this
MLA
Copy
Soh, Hosim, et al. “Atopic Diseases Are Associated With Development of Inflammatory Bowel Diseases in Korea: A Nationwide Population-based Study.” Clinical Gastroenterology and Hepatology, vol. 19, no. 10, Oct. 2021, pp. 2072-2081000000. https://doi.org/10.1016/j.cgh.2020.07.049.