Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial
Benjamin Thiele
1
,
Alexander Stein
1, 2
,
Christoph Schultheiß
1
,
L. Paschold
1, 3
,
Hanna Jonas
1, 3
,
Eray Goekkurt
1, 4
,
Jörn Rüssel
1, 3
,
G. Schuch
1, 5
,
Jan Wierecky
1, 6
,
Marianne Sinn
1, 7
,
Joseph Tintelnot
1, 7
,
C. S. PETERSEN
1, 8
,
K Rothkamm
1, 8
,
Eik Vettorazzi
1, 9
,
Mascha Binder
1, 10
2
4
5
Hämatologisch- Onkologische Praxis Altona, Hamburg, Germany.
|
6
Überörtliche Gemeinschaftspraxis für Innere Medizin Schwerpunkt Hämatologie, Onkologie und Palliativmedizin, Hamburg, Germany.
|
7
8
Publication type: Journal Article
Publication date: 2025-03-01
scimago Q1
wos Q2
SJR: 1.187
CiteScore: 6.2
Impact factor: 3.2
ISSN: 15330028, 19380674
PubMed ID:
39003182
Abstract
Optimizing functional outcomes and securing long-term remissions are key goals in managing patients with locally advanced rectal cancer. In this proof-of-concept study, we set out to further optimize neoadjuvant therapy by integrating the radiosensitizer trifluridine/tipiracil and explore the potential of cell free tumor DNA (ctDNA) to monitor residual disease.
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Thiele B. et al. Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial // Clinical Colorectal Cancer. 2025. Vol. 24. No. 1. pp. 11-17.
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Thiele B. et al. Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial // Clinical Colorectal Cancer. 2025. Vol. 24. No. 1. pp. 11-17.
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TY - JOUR
DO - 10.1016/j.clcc.2024.06.003
UR - https://linkinghub.elsevier.com/retrieve/pii/S1533002824000598
TI - Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial
T2 - Clinical Colorectal Cancer
AU - Thiele, Benjamin
AU - Stein, Alexander
AU - Schultheiß, Christoph
AU - Paschold, L.
AU - Jonas, Hanna
AU - Goekkurt, Eray
AU - Rüssel, Jörn
AU - Schuch, G.
AU - Wierecky, Jan
AU - Sinn, Marianne
AU - Tintelnot, Joseph
AU - PETERSEN, C. S.
AU - Rothkamm, K
AU - Vettorazzi, Eik
AU - Binder, Mascha
PY - 2025
DA - 2025/03/01
PB - Elsevier
SP - 11-17
IS - 1
VL - 24
PMID - 39003182
SN - 1533-0028
SN - 1938-0674
ER -
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BibTex (up to 50 authors)
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@article{2025_Thiele,
author = {Benjamin Thiele and Alexander Stein and Christoph Schultheiß and L. Paschold and Hanna Jonas and Eray Goekkurt and Jörn Rüssel and G. Schuch and Jan Wierecky and Marianne Sinn and Joseph Tintelnot and C. S. PETERSEN and K Rothkamm and Eik Vettorazzi and Mascha Binder and others},
title = {Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial},
journal = {Clinical Colorectal Cancer},
year = {2025},
volume = {24},
publisher = {Elsevier},
month = {mar},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1533002824000598},
number = {1},
pages = {11--17},
doi = {10.1016/j.clcc.2024.06.003}
}
Cite this
MLA
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Thiele, Benjamin, et al. “Trifluridine/tipiracil based chemoradiation in locally advanced rectal cancer - The phase I/II TARC trial.” Clinical Colorectal Cancer, vol. 24, no. 1, Mar. 2025, pp. 11-17. https://linkinghub.elsevier.com/retrieve/pii/S1533002824000598.