Benefits of Metformin in Attenuating the Hallmarks of Aging
Тип публикации: Journal Article
Дата публикации: 2020-07-01
scimago Q1
wos Q1
БС1
SJR: 11.989
CiteScore: 45.5
Impact factor: 30.9
ISSN: 15504131, 19327420
PubMed ID:
32333835
Molecular Biology
Cell Biology
Physiology
Краткое описание
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial-TAME (targeting aging by metformin). This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
2
4
6
8
10
12
14
16
18
|
|
|
Ageing Research Reviews
18 публикаций, 3.03%
|
|
|
International Journal of Molecular Sciences
17 публикаций, 2.86%
|
|
|
Aging
11 публикаций, 1.85%
|
|
|
Cells
10 публикаций, 1.68%
|
|
|
Frontiers in Pharmacology
7 публикаций, 1.18%
|
|
|
Frontiers in Aging
7 публикаций, 1.18%
|
|
|
GeroScience
7 публикаций, 1.18%
|
|
|
Aging Cell
7 публикаций, 1.18%
|
|
|
Frontiers in Endocrinology
6 публикаций, 1.01%
|
|
|
Pharmaceuticals
6 публикаций, 1.01%
|
|
|
Signal Transduction and Targeted Therapy
6 публикаций, 1.01%
|
|
|
Biogerontology
6 публикаций, 1.01%
|
|
|
Experimental Gerontology
6 публикаций, 1.01%
|
|
|
Frontiers in Immunology
5 публикаций, 0.84%
|
|
|
Journals of Gerontology - Series A Biological Sciences and Medical Sciences
5 публикаций, 0.84%
|
|
|
Antioxidants
4 публикации, 0.67%
|
|
|
Cardiovascular Diabetology
4 публикации, 0.67%
|
|
|
Mechanisms of Ageing and Development
4 публикации, 0.67%
|
|
|
Biomedicine and Pharmacotherapy
4 публикации, 0.67%
|
|
|
Cell Metabolism
4 публикации, 0.67%
|
|
|
iScience
4 публикации, 0.67%
|
|
|
Biomedicines
4 публикации, 0.67%
|
|
|
Oxidative Medicine and Cellular Longevity
4 публикации, 0.67%
|
|
|
Nutrients
3 публикации, 0.51%
|
|
|
Frontiers in Oncology
3 публикации, 0.51%
|
|
|
Frontiers in Genetics
3 публикации, 0.51%
|
|
|
Frontiers in Cell and Developmental Biology
3 публикации, 0.51%
|
|
|
Nature Reviews Endocrinology
3 публикации, 0.51%
|
|
|
Scientific Reports
3 публикации, 0.51%
|
|
|
2
4
6
8
10
12
14
16
18
|
Издатели
|
20
40
60
80
100
120
140
160
180
|
|
|
Elsevier
169 публикаций, 28.45%
|
|
|
Springer Nature
116 публикаций, 19.53%
|
|
|
MDPI
61 публикация, 10.27%
|
|
|
Frontiers Media S.A.
46 публикаций, 7.74%
|
|
|
Wiley
45 публикаций, 7.58%
|
|
|
Cold Spring Harbor Laboratory
20 публикаций, 3.37%
|
|
|
Oxford University Press
19 публикаций, 3.2%
|
|
|
Impact Journals
11 публикаций, 1.85%
|
|
|
Taylor & Francis
11 публикаций, 1.85%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
8 публикаций, 1.35%
|
|
|
Hindawi Limited
8 публикаций, 1.35%
|
|
|
American Chemical Society (ACS)
5 публикаций, 0.84%
|
|
|
American Diabetes Association
4 публикации, 0.67%
|
|
|
Pleiades Publishing
4 публикации, 0.67%
|
|
|
BMJ
3 публикации, 0.51%
|
|
|
American Association for the Advancement of Science (AAAS)
3 публикации, 0.51%
|
|
|
American Physiological Society
3 публикации, 0.51%
|
|
|
eLife Sciences Publications
3 публикации, 0.51%
|
|
|
Annual Reviews
3 публикации, 0.51%
|
|
|
The Company of Biologists
2 публикации, 0.34%
|
|
|
Mary Ann Liebert
2 публикации, 0.34%
|
|
|
Aging and Disease
2 публикации, 0.34%
|
|
|
Association for Research in Vision and Ophthalmology (ARVO)
2 публикации, 0.34%
|
|
|
SAGE
2 публикации, 0.34%
|
|
|
Bentham Science Publishers Ltd.
2 публикации, 0.34%
|
|
|
Oriental Scientific Publishing Company
2 публикации, 0.34%
|
|
|
OAE Publishing Inc.
2 публикации, 0.34%
|
|
|
Science Alert
2 публикации, 0.34%
|
|
|
IMR Press
2 публикации, 0.34%
|
|
|
20
40
60
80
100
120
140
160
180
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
594
Всего цитирований:
594
Цитирований c 2024:
249
(41.92%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Kulkarni A. S., Gubbi S., Barzilai N. Benefits of Metformin in Attenuating the Hallmarks of Aging // Cell Metabolism. 2020. Vol. 32. No. 1. pp. 15-30.
ГОСТ со всеми авторами (до 50)
Скопировать
Kulkarni A. S., Gubbi S., Barzilai N. Benefits of Metformin in Attenuating the Hallmarks of Aging // Cell Metabolism. 2020. Vol. 32. No. 1. pp. 15-30.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1016/j.cmet.2020.04.001
UR - https://doi.org/10.1016/j.cmet.2020.04.001
TI - Benefits of Metformin in Attenuating the Hallmarks of Aging
T2 - Cell Metabolism
AU - Kulkarni, Ameya S.
AU - Gubbi, Sriram
AU - Barzilai, N.
PY - 2020
DA - 2020/07/01
PB - Elsevier
SP - 15-30
IS - 1
VL - 32
PMID - 32333835
SN - 1550-4131
SN - 1932-7420
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2020_Kulkarni,
author = {Ameya S. Kulkarni and Sriram Gubbi and N. Barzilai},
title = {Benefits of Metformin in Attenuating the Hallmarks of Aging},
journal = {Cell Metabolism},
year = {2020},
volume = {32},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.cmet.2020.04.001},
number = {1},
pages = {15--30},
doi = {10.1016/j.cmet.2020.04.001}
}
Цитировать
MLA
Скопировать
Kulkarni, Ameya S., et al. “Benefits of Metformin in Attenuating the Hallmarks of Aging.” Cell Metabolism, vol. 32, no. 1, Jul. 2020, pp. 15-30. https://doi.org/10.1016/j.cmet.2020.04.001.