Open Access

Colloids and Interface Science Communications

, volume 35 , pages 100235

CD44 receptor targeted ‘smart’ multi-walled carbon nanotubes for synergistic therapy of triple-negative breast cancer

Nidhi Jain Singhai ¹

Shubham Srivastava ²

Suman Ramteke ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal 462033, MP, India |

School of Pharmacy and Technology Management, SVKM's NMIMS, Hyderabad, Telangana 509 301, India |

Publication type: Journal Article

Publication date: 2020-03-01

Elsevier

Colloids and Interface Science Communications

scimago Q1

wos Q2

SJR: 0.842

CiteScore: 11.6

Impact factor: 4.7

ISSN: 22150382

DOI: 10.1016/j.colcom.2020.100235

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Materials Chemistry

Surfaces, Coatings and Films

Physical and Theoretical Chemistry

Colloid and Surface Chemistry

Biotechnology

Abstract

Triple-negative breast cancer requires high treatment specificity and efficacy due to its aggressive nature. In the present investigation, multi-walled carbon-nanotubes (MWCNTs) were functionalized using Hyaluronic acid (HA) and α-Tocopheryl succinate (α-TOS) and loaded with Doxorubicin (Dox) to obtained novel α-TOS-HA-MWCNTs/Dox conjugate to achieve enhanced cellular-placement and anticancer-therapeutic action against CD44 receptors overexpressing TNBC cells (MDA-MB-231). Interestingly, α-TOS-HA-MWCNTs/Dox displayed high cellular uptake as compared to individually tailored MWCNTs formulations. Anticancer investigation revealed prominent growth inhibition effect (SRB assay; GI50; 0.810 ± 0.017; p

Found

2 citations

Saraf Shubhini

156 publications, 3 038 citations, 24 reviews

h-index: 29

Babasaheb Bhimrao Ambedkar University

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Singhai N. J., Srivastava S., Ramteke S. CD44 receptor targeted ‘smart’ multi-walled carbon nanotubes for synergistic therapy of triple-negative breast cancer // Colloids and Interface Science Communications. 2020. Vol. 35. p. 100235.

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RIS Copy

TY - JOUR

DO - 10.1016/j.colcom.2020.100235

UR - https://doi.org/10.1016/j.colcom.2020.100235

TI - CD44 receptor targeted ‘smart’ multi-walled carbon nanotubes for synergistic therapy of triple-negative breast cancer

T2 - Colloids and Interface Science Communications

AU - Singhai, Nidhi Jain

AU - Srivastava, Shubham

AU - Ramteke, Suman

PY - 2020

DA - 2020/03/01

PB - Elsevier

SP - 100235

VL - 35

SN - 2215-0382

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2020_Singhai,

author = {Nidhi Jain Singhai and Shubham Srivastava and Suman Ramteke},

title = {CD44 receptor targeted ‘smart’ multi-walled carbon nanotubes for synergistic therapy of triple-negative breast cancer},

journal = {Colloids and Interface Science Communications},

year = {2020},

volume = {35},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.colcom.2020.100235},

pages = {100235},

doi = {10.1016/j.colcom.2020.100235}

}

Publisher

Elsevier

Journal

Colloids and Interface Science Communications

scimago Q1

wos Q2

SJR

0.842

CiteScore

11.6

Impact factor

4.7

ISSN

22150382 (Print, Electronic)