Unveiling the Molecular Mechanisms of Haitang-Xiaoyin Mixture in Psoriasis Treatment based on Bioinformatics, Network Pharmacology, Machine Learning, and Molecular Docking Verification
Manyin Zhai
1
,
Tongxiu Chen
1
,
Mengqiu Shao
1
,
Xuesong Yang
2
,
Qi Yan
3
,
Sai Kong
4
,
Lijuan Jiang
3
,
Enpin Yang
2
1
Тип публикации: Journal Article
Дата публикации: 2025-04-01
scimago Q2
wos Q1
БС1
SJR: 0.522
CiteScore: 4.3
Impact factor: 3.1
ISSN: 14769271, 1476928X
Краткое описание
ObjectivePsoriasis is a common clinical skin inflammatory disease. Haitang-Xiaoyin Mixture (HXM) represents a traditional Chinese medicine formulation utilized clinically for the management of psoriasis, which can reduce the psoriasis area and severity index (PASI) score, IL-23 and IL-23 levels in patients with psoriasis. However, the main active components and specific targets of HXM in the treatment of psoriasis and the relevant mechanisms of action are not clear. Therefore, in the study we aimed to elucidate the mechanistic basis of HXM's therapeutic action in psoriasis treatment through the application of bioinformatics, network pharmacology, machine learning and molecular docking methodologies.
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Zhai M. et al. Unveiling the Molecular Mechanisms of Haitang-Xiaoyin Mixture in Psoriasis Treatment based on Bioinformatics, Network Pharmacology, Machine Learning, and Molecular Docking Verification // Computational Biology and Chemistry. 2025. Vol. 115. p. 108352.
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Zhai M., Chen T., Shao M., Yang X., Qi Yan, Kong S., Jiang L., Yang E. Unveiling the Molecular Mechanisms of Haitang-Xiaoyin Mixture in Psoriasis Treatment based on Bioinformatics, Network Pharmacology, Machine Learning, and Molecular Docking Verification // Computational Biology and Chemistry. 2025. Vol. 115. p. 108352.
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TY - JOUR
DO - 10.1016/j.compbiolchem.2025.108352
UR - https://linkinghub.elsevier.com/retrieve/pii/S147692712500012X
TI - Unveiling the Molecular Mechanisms of Haitang-Xiaoyin Mixture in Psoriasis Treatment based on Bioinformatics, Network Pharmacology, Machine Learning, and Molecular Docking Verification
T2 - Computational Biology and Chemistry
AU - Zhai, Manyin
AU - Chen, Tongxiu
AU - Shao, Mengqiu
AU - Yang, Xuesong
AU - Qi Yan
AU - Kong, Sai
AU - Jiang, Lijuan
AU - Yang, Enpin
PY - 2025
DA - 2025/04/01
PB - Elsevier
SP - 108352
VL - 115
SN - 1476-9271
SN - 1476-928X
ER -
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@article{2025_Zhai,
author = {Manyin Zhai and Tongxiu Chen and Mengqiu Shao and Xuesong Yang and Qi Yan and Sai Kong and Lijuan Jiang and Enpin Yang},
title = {Unveiling the Molecular Mechanisms of Haitang-Xiaoyin Mixture in Psoriasis Treatment based on Bioinformatics, Network Pharmacology, Machine Learning, and Molecular Docking Verification},
journal = {Computational Biology and Chemistry},
year = {2025},
volume = {115},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S147692712500012X},
pages = {108352},
doi = {10.1016/j.compbiolchem.2025.108352}
}