Current applications of poly(lactic acid) composites in tissue engineering and drug delivery
Publication type: Journal Article
Publication date: 2020-10-01
scimago Q1
wos Q1
SJR: 2.961
CiteScore: 25.6
Impact factor: 14.2
ISSN: 13598368
Ceramics and Composites
Mechanical Engineering
Industrial and Manufacturing Engineering
Mechanics of Materials
Abstract
Biodegradable poly(lactic acid) (PLA) presents suitable physicochemical properties and biocompatibility for biomedical engineering. However, PLA has some drawbacks, such as low cell adhesion, biological inertness, low degradation rate, and acid degradation by-products. In this review, recent progress on strategies to address these problems is summarized, including novel fabrication techniques, high-performance PLA composites, and their applications for tissue engineering and drug delivery. The scaffolds, especially for bone regeneration, blood vessels, organs, and skin regeneration are evaluated, in terms of in vivo and in vitro biocompatibility and biodegradability. The enhanced mechanical, thermal, and rheological properties of PLA biocomposites are analyzed in detail. PLA biocomposites for drug encapsulation, sustained release, and tumor-targeting are also reviewed. Furthermore, the challenges and future perspectives on PLA-based biocomposites are discussed.
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454
Total citations:
454
Citations from 2024:
202
(44.69%)
Cite this
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GOST
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Liu S. et al. Current applications of poly(lactic acid) composites in tissue engineering and drug delivery // Composites Part B: Engineering. 2020. Vol. 199. p. 108238.
GOST all authors (up to 50)
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Liu S., Qin S., He M., Zhou D., Qin Q., Wang H. Current applications of poly(lactic acid) composites in tissue engineering and drug delivery // Composites Part B: Engineering. 2020. Vol. 199. p. 108238.
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TY - JOUR
DO - 10.1016/j.compositesb.2020.108238
UR - https://doi.org/10.1016/j.compositesb.2020.108238
TI - Current applications of poly(lactic acid) composites in tissue engineering and drug delivery
T2 - Composites Part B: Engineering
AU - Liu, Shan-Lin
AU - Qin, Shuhao
AU - He, Min
AU - Zhou, Dengfeng
AU - Qin, Qingdong
AU - Wang, Hao
PY - 2020
DA - 2020/10/01
PB - Elsevier
SP - 108238
VL - 199
SN - 1359-8368
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Liu,
author = {Shan-Lin Liu and Shuhao Qin and Min He and Dengfeng Zhou and Qingdong Qin and Hao Wang},
title = {Current applications of poly(lactic acid) composites in tissue engineering and drug delivery},
journal = {Composites Part B: Engineering},
year = {2020},
volume = {199},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.compositesb.2020.108238},
pages = {108238},
doi = {10.1016/j.compositesb.2020.108238}
}