Elsevier
Current Pharmaceutical Analysis
,  том 21 ,  издание 10 ,  страницы 469-475

Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring

Тип публикации: Journal Article
Дата публикации: 2025-11-01
Elsevier
SCImago Q2
WOS Q4
БС3
SJR: 0.442
CiteScore: 1.7
Impact factor: 1.5
ISSN: 15734129, 1875676X
Краткое описание
BackgroundThe trough concentration (Cmin) of linezolid (LEN) is closely associated with therapeutic efficacy and adverse reactions in patients with complex Gram-positive bacterial infections. However, substantial inter- and intra-individual variability exists in plasma concentrations of this drug. Therefore, therapeutic drug monitoring (TDM) is strongly recommended. This study aimed to establish a rapid and simple two-dimensional high-performance liquid chromatography (2D-HPLC) method for determining plasma LEN concentrations for TDM and providing a scientific basis for its rational clinical use.
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Journal of Inorganic and Organometallic Polymers and Materials
Journal of Inorganic and Organometallic Polymers and Materials, 1, 100%
Journal of Inorganic and Organometallic Polymers and Materials
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Liu R. et al. Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring // Current Pharmaceutical Analysis. 2025. Vol. 21. No. 10. pp. 469-475.
ГОСТ со всеми авторами (до 50) Скопировать
Liu R., Xing Q., Liu Z., Li W., Yan Q., Chen K., Liu X. Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring // Current Pharmaceutical Analysis. 2025. Vol. 21. No. 10. pp. 469-475.
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TY - JOUR
DO - 10.1016/j.cpan.2025.09.008
UR - https://linkinghub.elsevier.com/retrieve/pii/S1573412925000878
TI - Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring
T2 - Current Pharmaceutical Analysis
AU - Liu, Renzhu
AU - Xing, Qichang
AU - Liu, Zheng
AU - Li, Wencan
AU - Yan, Qingzi
AU - Chen, Keqian
AU - Liu, Xiang
PY - 2025
DA - 2025/11/01
PB - Elsevier
SP - 469-475
IS - 10
VL - 21
SN - 1573-4129
SN - 1875-676X
ER -
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@article{2025_Liu,
author = {Renzhu Liu and Qichang Xing and Zheng Liu and Wencan Li and Qingzi Yan and Keqian Chen and Xiang Liu},
title = {Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring},
journal = {Current Pharmaceutical Analysis},
year = {2025},
volume = {21},
publisher = {Elsevier},
month = {nov},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1573412925000878},
number = {10},
pages = {469--475},
doi = {10.1016/j.cpan.2025.09.008}
}
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Liu, Renzhu, et al. “Two-Dimensional HPLC Method for Determining Linezolid Concentrations in Plasma and Its Clinical Application in Therapeutic Drug Monitoring.” Current Pharmaceutical Analysis, vol. 21, no. 10, Nov. 2025, pp. 469-475. https://linkinghub.elsevier.com/retrieve/pii/S1573412925000878.
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