The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy
Qingyu Jiang
1, 2, 3, 4
,
Chen Zhiheng
5
,
Jin Jiang
5
,
Qianping Chen
1, 3, 4
,
Huiyin Lan
1, 3, 4
,
Ji Zhu
1, 3, 4
,
Wei Mao
1, 3, 4
1
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310000, China
|
3
Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310000, China
|
4
Zhejiang Key Laboratory of Radiation Oncology, Hangzhou 310000, China
|
Publication type: Journal Article
Publication date: 2025-05-01
scimago Q1
wos Q1
SJR: 1.820
CiteScore: 10.4
Impact factor: 5.6
ISSN: 10408428, 18790461
Abstract
The activation of the cGAS-STING pathway occurs when tumor cell DNA is damaged by ionizing radiation. Once triggered, this pathway reshapes the tumor immune microenvironment by promoting the maturation, activation, polarization, and immune-killing capacity of immune cells, as well as by inducing the release of interferons and the expression of immune-related genes. In addition, the gut microbiota and various mechanisms of programmed cell death interact with the cGAS-STING pathway, further influencing its function in remodeling the immune microenvironment after radiotherapy. Therefore, investigating the mechanisms of the cGAS-STING pathway in reshaping the tumor immune microenvironment post-radiotherapy can not only optimize the efficacy of combined radiotherapy and immunotherapy but also provide new research directions and potential targets for cancer treatment.
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Total citations:
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Citations from 2024:
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(100%)
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Jiang Q. et al. The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy // Critical Reviews in Oncology/Hematology. 2025. Vol. 209. p. 104658.
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Jiang Q., Chen Zhiheng, Jiang J., Chen Q., Lan H., Zhu J., Mao W. The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy // Critical Reviews in Oncology/Hematology. 2025. Vol. 209. p. 104658.
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TY - JOUR
DO - 10.1016/j.critrevonc.2025.104658
UR - https://linkinghub.elsevier.com/retrieve/pii/S1040842825000460
TI - The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy
T2 - Critical Reviews in Oncology/Hematology
AU - Jiang, Qingyu
AU - Chen Zhiheng
AU - Jiang, Jin
AU - Chen, Qianping
AU - Lan, Huiyin
AU - Zhu, Ji
AU - Mao, Wei
PY - 2025
DA - 2025/05/01
PB - Elsevier
SP - 104658
VL - 209
SN - 1040-8428
SN - 1879-0461
ER -
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@article{2025_Jiang,
author = {Qingyu Jiang and Chen Zhiheng and Jin Jiang and Qianping Chen and Huiyin Lan and Ji Zhu and Wei Mao},
title = {The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy},
journal = {Critical Reviews in Oncology/Hematology},
year = {2025},
volume = {209},
publisher = {Elsevier},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1040842825000460},
pages = {104658},
doi = {10.1016/j.critrevonc.2025.104658}
}